Tacrolimus Capsules PROGRAF®) 1?mg – For Laboratory Research Use Only
$1.00
PROGRAF® Tacrolimus Capsules are 1?mg each, supplied in a 100?capsule bottle. Produced under license from Astellas Ireland and packaged by Astellas China, approved by NMPA under J20150102. Intended exclusively for laboratory research use; wholesale and retail supported.?For wholesale prices, other specifications and uses, please consult our staff?
描述
Tacrolimus is a potent calcineurin?inhibitor immunosuppressant used extensively in research to study T?lymphocyte activation, cytokine regulation, and transplant rejection models. Originally derived from Streptomyces tsukubaensis, tacrolimus binds FKBP?12 to inhibit calcineurin, reducing IL?2 and other cytokines, thus suppressing T-cell mediated immune responses.
These capsules are the PROGRAF®-branded formulation, each containing 1?mg tacrolimus. Manufactured by Astellas Ireland Co. Ltd and packaged in China by Astellas, under NMPA approval number J20150102. Not intended for clinical use—strictly for laboratory research.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Tacrolimus Capsules (PROGRAF®) |
| Generic Name | Tacrolimus |
| CAS Number | 104987-11-3 |
| Molecular Formula | C44H69NO12·H?O |
| Molecular Weight | 822.03?g/mol |
| Dosage Form | Oral capsules |
| Strength | 1?mg per capsule |
| Quantity per Bottle | 100 capsules |
| Approval Number | J20150102 (China NMPA) |
| Manufacturer | Astellas Ireland Co. Ltd.; packaged in China |
| Barcode | Not recorded; contact online pharmacist |
| Intended Use | Laboratory research only |
| Storage Conditions | Store in a cool, dry place below 25?°C |
Mechanism of Action & Research Applications
Tacrolimus works by forming a complex with FKBP?12, which then inhibits calcineurin phosphatase activity. This action prevents NF?AT and NF??B activation and suppresses cytokine production such as IL?2, IL?4, IL?6, TNF??, and interferon??.
In laboratory research, tacrolimus capsules are used to:
-
Model transplant rejection and prevention
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Study T-lymphocyte activation and signaling pathways
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Evaluate immunosuppressive effects in cell or animal models
-
Investigate cytokine regulation and immune modulation
Side Effects (For Reference Only in Experimental Models)
In controlled research settings, tacrolimus may cause:
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Suppression of T-cell activation
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Altered cytokine expression
-
Potential nephrotoxicity or neurotoxicity at high exposures
-
Dose-dependent effects on systemic metabolism
These are experimental observations and not indicative of clinical safety.
Disclaimer
Tacrolimus Capsules (PROGRAF®) are for laboratory research use only and not intended for human or veterinary therapeutic use. Use must adhere to institutional biosafety and research safety protocols.
其他信息
| 重量 | 1 公斤 |
|---|---|
| 尺寸 | 26 × 23 × 26 厘米 |
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