Tadalafil Tablets 20?mg – Research Use Only
$1.00
Tadalafil is a potent, selective phosphodiesterase?5 (PDE5) inhibitor traditionally used for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary hypertension. This 20?mg oral tablet is supplied for laboratory and preclinical research use only, and is not approved for clinical, diagnostic, therapeutic, or veterinary applications.
描述
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Tadalafil Tablets (Jian Ning® / Xinhua Pharmaceutical) |
| Generic Name | Tadalafil (C???H??N?O?) |
| CAS Number | 171596?29?5 ncbi.nlm.nih.goven.wikipedia.org+11pubchem.ncbi.nlm.nih.gov+11store.usp.org+11 |
| Molecular Formula | C??H??N?O? |
| Molecular Weight | ?389.4?g/mol |
| Dosage Form | Film-coated oral tablet (film tab) |
| Strength | 20?mg per tablet |
| Pack Size | 1 tablet per box |
| Approval Number | China NMPA H20234680 |
| Product Code | 86901447001547 |
| Manufacturer | Shandong Zibo Xinda Pharmaceutical Co., Ltd. |
| Barcode | 6921675343084 |
| Storage Conditions | Store in a cool, dry place at 15–25?°C; keep out of reach of direct light |
| Intended Use | Laboratory research only |
Mechanism of Action
Tadalafil works by selectively inhibiting PDE5, increasing intracellular cGMP levels. This leads to smooth muscle relaxation and vasodilation—widely studied in penile erection, bladder function (BPH), and pulmonary blood pressure regulation.
Research Applications & Pharmacology
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Erectile Dysfunction (ED) Models: Widely used to study PDE5 inhibition and vascular responses .
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Benign Prostatic Hyperplasia (BPH): Investigated for smooth muscle relaxation in prostatic and urinary tract tissues .
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Pulmonary Hypertension (PAH): Employed in animal models to evaluate pulmonary vascular effects .
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Pharmacokinetics: Oral bioavailability varies; half-life ~17.5?hours; duration ~36?hours; metabolized via CYP3A4, excreted in feces (~61%) and urine (~36%) .
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Safety & Adverse Effects in Research: Common effects include headache, flushing, muscle pain, and mild hypotension; monitor cardiovascular parameters in vivo .
Safety Profile & Handling
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Adverse Events: Research highlights mild dizziness, flushing, nasopharyngitis, back pain, and rare visual/auditory disturbances .
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Drug Interactions: Strong vasodilatory effects—avoid co-administration with nitrates or alpha?blockers in in vivo models accessdata.fda.gov.
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Handling Guidelines: Use with appropriate PPE; store under recommended conditions; discard expired tablets per safety protocol.
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Contraindications for Research Models: Exercise caution in cardiovascular-compromised animal models; mimic clinical contraindications.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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