Description

TAK-448 Acetate (also known as MVT-602 Acetate) is a lab-designed nonapeptide mimicking the active segment of kisspeptin-54. As a powerful and selective KISS1R (GPR54) receptor agonist, it triggers rapid release of LH and FSH in acute dosing but suppresses the entire pituitary-gonadal axis with sustained exposure, resulting in profound testosterone reduction. Remarkably, TAK-448 exhibits potent anti-tumor efficacy in androgen-sensitive prostate cancer animal models, reducing PSA levels and tumor growth in a dose-dependent manner.

Constructed under GMP manufacturing standards with a purity of at least 99.70%, this analog provides high reproducibility for advanced endocrine, oncology, and reproductive biology research.

Product Category

Peptide Endocrine Modulators — synthetic peptides engineered to regulate hormone pathways, utilized in tumor biology, reproductive studies, and endocrine signaling research.

Product Specifications

Mechanism of Action & Research Applications

TAK-448 Acetate binds KISS1R (GPR54), initially stimulating LH and FSH release, but leads to receptor regulation and sustained suppression of the pituitary-gonadal axis with continuous exposure—resulting in significantly reduced testosterone levels. In androgen-dependent prostate cancer models, it significantly reduces prostate-specific antigen (PSA) and tumor volume, showcasing its potential as a research tool for hormone-dependent tumor suppression.

Use cases include:

• Investigating endocrine regulation and feedback mechanisms

• Modeling androgen deprivation therapy in prostate cancer research

• Exploring novel therapeutic pathways for hormone-sensitive tumors

• Probing reproductive endocrine physiology

Side Effects (For Research Context Only)

In vivo studies report dose-dependent endocrine modulation, particularly testosterone suppression. Researchers should monitor hormonal levels to avoid over-suppression which could affect testicular or sexual function in models. Other systemic effects appear minimal at typical research dosages.

Logistics Transportation

All shipments are fully insured to ensure fast, secure delivery. Customers receive 100% compensation for any lost, damaged, or detained shipments.

Disclaimer

TAK-448 Acetate is intended strictly for laboratory research use. It is not approved for clinical, diagnostic, or therapeutic applications.