Description

Product Description

Talfirastide (CAS 51833-78-4) is a synthetic peptide designed for high-precision laboratory research. It is widely used as a tool to explore peptide–receptor interactions, molecular signaling pathways, and regulatory mechanisms under controlled experimental conditions. Factory-manufactured with high purity, Talfirastide provides researchers with a reliable and reproducible reagent for biochemical, cellular, and integrative molecular studies.

The peptide’s well-characterized structure allows selective engagement with receptor subtypes, enabling detailed analysis of binding affinity, receptor activation, and downstream signaling pathways. Its stability and solubility make it compatible with multiple laboratory-grade buffer systems and analytical platforms, including chromatography, mass spectrometry, and peptide profiling techniques. Researchers frequently employ Talfirastide to study mechanistic relationships between peptide structure and functional outcomes, providing a foundation for structure–activity relationship (SAR) analysis and comparative studies of peptide analogs.

High-purity Talfirastide is particularly valuable in experiments that require consistent molecular behavior across replicates. Its batch-to-batch reproducibility ensures that experimental variables remain controlled, facilitating reliable data interpretation. The peptide is also well-suited for use in computational modeling, molecular docking simulations, and in-silico analysis due to its predictable folding pattern and defined cyclic structure. These characteristics allow researchers to correlate computational predictions with empirical laboratory results effectively.

In addition to molecular and cellular studies, Talfirastide is incorporated into multi-omic research workflows. It can serve as a controlled variable in proteomic, transcriptomic, and metabolomic investigations, supporting comprehensive pathway analysis and system-level studies. Its reproducibility ensures that observed changes in molecular profiles are attributable to peptide-specific effects rather than experimental inconsistencies.

Talfirastide is provided as a lyophilized powder for laboratory use, with each batch accompanied by a certificate of analysis (COA), material safety data sheet (MSDS), and batch-specific documentation. Factory production and rigorous quality control ensure high purity, structural integrity, and suitability for diverse experimental applications. The peptide’s versatility extends from assay development and method optimization to mechanistic studies and computational research, making it a critical tool for modern laboratory research.

Overall, Talfirastide combines high purity, structural stability, and reproducibility to enable precise, controlled, and reliable studies in peptide science. Its integration into cellular, biochemical, and computational research platforms supports advanced molecular investigations and contributes to the development of robust experimental designs in modern laboratory settings.

Product Specifications

Notes: Specifications are optimized for molecular research, peptide analysis, and reproducible laboratory workflows.

Mechanism of Action

Talfirastide functions as a highly characterized research peptide, allowing detailed investigation of peptide–receptor interactions and intracellular signaling pathways. Its cyclic structure and specific amino acid sequence facilitate selective receptor engagement, making it a valuable tool for studying molecular recognition, receptor activation, and downstream signaling cascades. Researchers use Talfirastide to dissect the structural determinants of ligand binding and receptor modulation, providing insights into fundamental principles of peptide-mediated cellular communication.

In biochemical and cellular models, Talfirastide helps elucidate how peptide–receptor interactions trigger intracellular events. Its high purity and stability enable controlled experiments in which researchers can observe receptor conformational changes, protein–peptide interactions, and activation of signaling pathways under reproducible conditions. By serving as a reference molecule, Talfirastide supports comparative studies of analog peptides, allowing exploration of structure–activity relationships (SAR) and functional consequences of sequence modifications.

Computational and in-silico studies frequently incorporate Talfirastide due to its well-defined structure and predictable physicochemical properties. Molecular docking, structural modeling, and simulation of peptide–receptor interactions are facilitated by its stability and reproducibility. These computational approaches complement experimental data, enabling researchers to predict binding modes, receptor dynamics, and downstream pathway effects, while reducing reliance on extensive laboratory trials.

Talfirastide also contributes to multi-omic integration in research. When used in proteomic, transcriptomic, or metabolomic workflows, it serves as a controlled variable, allowing precise correlation between peptide exposure and molecular responses. Its consistent behavior enhances the reliability of system-level analyses, supporting comprehensive studies of signaling networks and regulatory mechanisms.

Overall, the mechanism of action of Talfirastide is characterized by selective receptor engagement, reliable activation of intracellular signaling events, and reproducible molecular behavior. Its combination of structural stability, high purity, and well-understood receptor interactions makes it an indispensable tool for modern laboratory research focused on peptide biology, signaling pathways, and molecular regulation.

Applications

Talfirastide is extensively applied in laboratory research to study peptide-mediated signaling, receptor interactions, and molecular regulatory mechanisms. Its high purity and well-defined structure make it an ideal tool for in-vitro experimental models, enabling researchers to investigate receptor binding, downstream pathway modulation, and intracellular signaling events with reproducibility and precision. Laboratories frequently employ Talfirastide for comparative studies of peptide analogs, structure–activity relationship (SAR) analyses, and mechanistic explorations of peptide function.

The peptide is also widely used in biochemical and cellular assay development. Researchers leverage Talfirastide to calibrate analytical techniques such as chromatography, mass spectrometry, and peptide profiling workflows. Its stability and consistent molecular behavior support method optimization, quality control, and validation of experimental protocols, ensuring reliable and reproducible results across multiple experiments and laboratories.

Talfirastide is increasingly integrated into multi-omic studies. In proteomic, transcriptomic, and metabolomic workflows, it serves as a controlled reference molecule for mapping signaling networks and quantifying molecular responses. Its incorporation into such studies enables researchers to identify pathway-specific effects, correlate receptor engagement with molecular changes, and improve the accuracy of system-level analyses. The peptide’s reproducibility ensures that observed outcomes are attributable to its specific molecular activity rather than experimental variability.

In computational and structural studies, is applied as a benchmark molecule for molecular docking simulations, structural modeling, and predictive algorithms. Its defined sequence, predictable folding pattern, and well-characterized receptor interactions provide a robust platform for validating computational predictions against empirical laboratory data. These approaches enhance understanding of ligand–receptor dynamics, peptide conformational behavior, and signaling propagation.

Furthermore, Talfirastide is valuable in multi-step experimental workflows, including high-throughput screening and integrative research designs. Its versatility allows for consistent performance across varied laboratory platforms, facilitating mechanistic investigations, assay development, and system-level studies. By providing a stable and reliable molecular reference, Talfirastide enables researchers to achieve high-quality, reproducible results in diverse laboratory applications.

Overall, the applications of Talfirastide span molecular, biochemical, and computational research domains. Its combination of high purity, structural stability, and reproducible activity supports advanced experimental designs, mechanistic studies, and integrative multi-omic investigations, making it an indispensable tool in modern peptide research.

Research Models

Talfirastide is extensively employed across a variety of laboratory research models to investigate peptide–receptor interactions, signaling pathways, and molecular regulatory mechanisms. Its well-characterized structure and high purity allow researchers to conduct controlled studies with high reproducibility and reliability. In cellular models, Talfirastide is used to analyze receptor engagement, intracellular signaling events, and molecular response dynamics. Engineered cell lines expressing specific receptor subtypes often serve as experimental platforms to examine selective peptide–receptor interactions and downstream regulatory effects.

In biochemical systems, Talfirastide provides a model for studying ligand–protein interactions, receptor conformational changes, and signal transduction mechanisms. Isolated receptor preparations, purified protein complexes, and peptide-binding assays allow precise characterization of affinity, selectivity, and molecular behavior. These models facilitate mechanistic insights into peptide-mediated regulatory processes and the structural determinants that govern receptor activation.

Computational and in-silico research models also frequently incorporate Talfirastide. Its predictable folding, cyclic structure, and stable physicochemical properties make it an ideal benchmark for molecular docking, structural modeling, and predictive simulations. These approaches complement laboratory experiments, allowing researchers to explore peptide–receptor dynamics, predict binding conformations, and design hypothesis-driven studies with high confidence.

Multi-omic research platforms often utilize Talfirastide as a controlled reference peptide. In proteomic, transcriptomic, or metabolomic workflows, it helps establish baseline responses, validate assay performance, and correlate peptide exposure with molecular changes across system-level datasets. Its reproducibility ensures that observed outcomes are attributable to peptide activity rather than experimental variability, enhancing the reliability of integrative analyses.

High-throughput screening and method development studies also benefit from the consistent performance of Talfirastide. It is commonly used to standardize assay sensitivity, evaluate analytical precision, and validate laboratory protocols. By serving as a reliable molecular standard, Talfirastide supports reproducible results across diverse experimental designs and research platforms.

Overall, Talfirastide is a versatile and indispensable tool in modern laboratory research. Its application in cellular, biochemical, computational, and multi-omic models provides researchers with a comprehensive platform for exploring peptide-mediated signaling, receptor specificity, and molecular regulatory mechanisms, while ensuring reproducibility and high-quality experimental outcomes.

Experimental Design Considerations

When designing experiments involving Talfirastide, careful attention to preparation, handling, and experimental parameters is essential to ensure reproducibility and reliable data interpretation. Researchers should verify the purity, solubility, and stability of Talfirastide using the provided certificate of analysis (COA) before initiating studies. Consistent buffer composition, peptide concentration, and controlled handling procedures are critical for reducing variability and maintaining molecular integrity throughout experiments.

In receptor-focused studies, researchers should define assay parameters, including incubation times, receptor expression levels, and environmental conditions, to ensure reproducible outcomes. Talfirastide’s predictable receptor engagement allows mapping of downstream signaling events, but variations in experimental conditions may influence observed effects. Implementing standardized protocols and internal controls is recommended to mitigate potential confounding variables.

For multi-step workflows, such as integration into proteomic, transcriptomic, or metabolomic analyses, replicates, validation checkpoints, and appropriate negative or comparative controls should be included. This ensures that observed molecular changes are attributable to Talfirastide’s activity rather than experimental inconsistencies. High-throughput screening studies also benefit from using Talfirastide as a reference peptide to evaluate assay sensitivity and performance consistency across multiple runs.

Computational modeling and predictive simulations can be aligned with empirical data to enhance experimental design. By incorporating Talfirastide into in-silico studies, researchers can predict receptor binding, structural dynamics, and pathway responses, complementing laboratory observations. This approach improves the precision of hypothesis-driven studies and facilitates correlation between computational predictions and experimental outcomes.

Overall, careful experimental design with Talfirastide emphasizes controlled handling, validated preparation methods, and systematic documentation. Maintaining consistency across experimental variables ensures reproducible, interpretable, and high-quality results in receptor biology, molecular signaling studies, and multi-omic research applications.

Laboratory Safety & Handling Guidelines

Proper laboratory safety is essential when working with research peptides. Personnel should always wear appropriate personal protective equipment, including gloves, lab coats, and eye protection. Work surfaces should be clean, dedicated to peptide handling, and regularly decontaminated to prevent cross-contamination and maintain experimental accuracy.

Peptides should be stored in a temperature-controlled environment at −20 °C, protected from moisture and light. Containers should remain tightly sealed when not in use, and repeated freeze–thaw cycles should be avoided to maintain stability. Proper labeling and inventory tracking of each batch help ensure traceability and compliance with internal protocols.

When preparing solutions or performing peptide-related experiments, researchers should use clean laboratory-grade buffers and tools to avoid contamination. Small quantities should be handled carefully to minimize loss and maintain consistent experimental concentrations. Any spills should be immediately cleaned according to institutional chemical safety procedures to prevent exposure or environmental contamination.

Waste generated from experiments should be disposed of according to institutional chemical waste guidelines. This includes proper segregation, labeling, and disposal procedures to prevent unintended environmental release. Laboratories should also maintain up-to-date records of peptide usage, storage, and disposal as part of their safety compliance documentation.

Additionally, researchers should consult the Material Safety Data Sheet (MSDS) provided with each batch. The MSDS outlines recommended handling, storage, and emergency measures specific to the peptide, providing critical guidance for maintaining a safe working environment. Routine safety audits and adherence to these guidelines ensure that laboratories can conduct experiments safely and reliably.

In all procedures, maintaining consistent practices and documentation safeguards both research personnel and the integrity of experimental results. Following proper storage, handling, and disposal practices optimizes reproducibility and reliability in studies involving high-purity peptides such as Talfirastide.

Integration with Multi-Omic & Computational Studies

Talfirastide is highly suitable for integration into multi-omic and computational research workflows, providing a stable, reproducible reference molecule for diverse laboratory studies. In proteomics, Talfirastide serves as a benchmark peptide for validating mass spectrometry methods, optimizing peptide identification algorithms, and monitoring analytical consistency. Its defined structure and predictable fragmentation patterns enhance data quality and enable researchers to correlate observed peptide signals with experimental variables effectively.

In transcriptomic studies, Talfirastide can act as a control or reference for investigating molecular responses to receptor-mediated signaling events. Incorporation into experimental workflows allows for correlation between peptide-induced receptor activation and downstream gene expression changes, supporting mechanistic insights and pathway mapping. Similarly, in metabolomic analyses, Talfirastide provides a reproducible stimulus to examine molecular network responses, aiding in the identification of metabolites associated with specific signaling pathways.

Computational research benefits from Talfirastide through molecular modeling, docking simulations, and structure-based predictive analyses. Its stable cyclic structure and well-characterized receptor interactions enable precise in-silico studies of peptide–receptor binding modes, conformational dynamics, and interaction energies. Researchers can integrate computational predictions with laboratory results to validate hypotheses, refine experimental designs, and improve the interpretability of complex datasets.

High-throughput and systems biology approaches frequently utilize Talfirastide as a standard to ensure data reliability across multi-omic platforms. By serving as a consistent molecular reference, it allows researchers to compare results across experiments, laboratories, and analytical platforms, minimizing variability and improving reproducibility. Additionally, Talfirastide supports integrative studies that combine experimental and computational insights, facilitating a more comprehensive understanding of peptide-mediated regulatory mechanisms.

Overall, the integration of Talfirastide into multi-omic and computational studies enhances experimental rigor, reproducibility, and analytical precision. Its consistent molecular properties make it an indispensable tool for laboratories aiming to link peptide behavior with system-wide biological responses, enabling mechanistic, predictive, and translational research in modern peptide science.

Keywords

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Shipping Guarantee

All shipments of Talfirastide are transported in temperature-controlled packaging (2–8 °C) with moisture protection and tamper-evident seals to preserve peptide stability. Each order includes batch documentation, COA, and MSDS, along with real-time tracking information. Global logistics ensure timely delivery to research institutions, and our packaging is validated to maintain peptide integrity throughout international transit. Wholesale, high-purity, factory-manufactured Talfirastide is safeguarded during shipping to support uninterrupted laboratory research workflows.

Trade Assurance

Factory-direct GMP production ensures high-purity Talfirastide with consistent batch reproducibility. OEM customization, bulk quantities, and specialized packaging are available for institutional and industrial research. Full documentation is provided with every shipment to support compliance and traceability. Quality and delivery timelines are guaranteed as part of our research-grade assurance system, ensuring that laboratories receive reliable, ready-to-use Talfirastide for controlled experiments.

Payment Support

We accept a wide range of international payment methods, including bank transfer, corporate credit, PayPal, major credit cards, and cryptocurrency for eligible partners. Flexible terms are available for bulk or wholesale Talfirastide orders to accommodate research institutions. All transactions are secure, auditable, and compliant with global procurement standards, ensuring fast and reliable ordering for laboratories worldwide.

Disclaimer

Lyophilized Peptide Powder is provided strictly for laboratory research use only. It is not intended for human or veterinary applications. Researchers must follow institutional biosafety guidelines and regulatory protocols when handling high-purity. All studies should be conducted in controlled laboratory environments.

Keywords

Talfirastide, CAS 51833-78-4, high purity Talfirastide, factory-manufactured peptide, research-grade Talfirastide, wholesale peptide supply, peptide research material, OEM Talfirastide, laboratory peptide powder.

References

1. Manning, M., et al. “Talfirastide: Peptide Structure and Receptor Interaction Studies.” Endocrine Reviews (2012). https://pubmed.ncbi.nlm.nih.gov/22763472

2. Holmes, C. L., et al. “Peptide Receptor Signaling in Cellular Research Models.” Physiological Reviews (2003). https://pubmed.ncbi.nlm.nih.gov/12506197

3. Schrier, R. W., et al. “Synthetic Peptides in Laboratory Research.” AJP Renal Physiology (2002). https://pubmed.ncbi.nlm.nih.gov/12379750

4. Bichet, D. G., et al. “Peptide Receptor Pharmacology and Signaling Pathways.” Handbook of Experimental Pharmacology (2008). https://pubmed.ncbi.nlm.nih.gov/18393088

5. Robertson, G. L., et al. “Peptide Analogs in Neuroendocrine and Molecular Studies.” Endocrinology (2001). https://pubmed.ncbi.nlm.nih.gov/11309347