Description

Tetracosactide Acetate, also known as Tetracosactrin Acetate, is a synthetic peptide derived from the adrenocorticotrophic hormone (ACTH) sequence. With a CAS number of 60189-34-6 and a verified purity of 99.26%, this compound is manufactured under GMP-certified conditions, ensuring consistency and high quality suitable for advanced laboratory applications.

Functionally, Tetracosactide Acetate is an agonist of the melanocortin-4 receptor (MC4R), activating this receptor with high potency (EC50 = 0.65 nM). This activity makes it an important research tool in exploring adrenal physiology, neuroendocrine signaling, and immune regulation. By mimicking the biological activity of ACTH, Tetracosactide Acetate stimulates the adrenal cortex to release corticosteroids such as cortisol, which play central roles in metabolism, inflammation, and immune response.

In research contexts, Tetracosactide Acetate has been widely investigated for its applications in autoimmune and inflammatory disease models, including ulcerative colitis, Crohn’s disease, juvenile/adult rheumatoid arthritis, and osteoarthrosis. These studies help scientists better understand the therapeutic potential of ACTH analogues in modulating immune responses and alleviating chronic inflammation.

Unlike the natural hormone, Tetracosactide Acetate provides a stable, synthetic form that can be studied in controlled conditions, making it especially valuable for preclinical pharmacology and biochemical studies.

This product is supplied as a high-purity peptide in its acetate salt form, which improves stability for laboratory use. It is designed exclusively for scientific research purposes and is not intended for clinical, veterinary, or human use.

Product Specifications

• Product Name: Tetracosactide Acetate (Tetracosactrin Acetate)

• CAS Number: 60189-34-6

• Synonyms: Tetracosactrin, ACTH (1-24) analogue, Corticotropin analogue

• Chemical Formula: C136H210N40O31S

• Molecular Weight: ~2933.4 g/mol

• Purity: 99.26% (HPLC)

• Form: Acetate salt, lyophilized powder

• Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro (ACTH 1-24 fragment)

• Receptor Activity: MC4R agonist (EC50 = 0.65 nM)

• Function: Stimulates corticosteroid release from adrenal glands

• Stability: Stable in acetate salt form under recommended storage

• Storage: Store at –20°C, protect from light and moisture

• Origin: GMP-Certified Manufacturer

• Applications: Research in endocrinology, immunology, inflammation, and autoimmune disease models

• Intended Use: For laboratory research only; not for diagnostic, therapeutic, or human consumption

Mechanism of Action & Research Applications

Tetracosactide Acetate functions as a synthetic analogue of adrenocorticotrophic hormone (ACTH). By binding to melanocortin receptors, particularly the melanocortin-2 receptor (MC2R) in adrenal glands and melanocortin-4 receptor (MC4R) in the central nervous system, it triggers a cascade of intracellular events that result in the production and release of glucocorticoids (cortisol), mineralocorticoids, and androgens.

This hormone-like activity makes it a valuable research tool in the study of:

1. Adrenal Function & Stress Response – Cortisol secretion plays a vital role in regulating stress responses, metabolism, and immune modulation. Tetracosactide Acetate is commonly used in laboratory tests to investigate adrenal gland activity and feedback mechanisms.

2. Autoimmune Disease Research – Due to its immunomodulatory effects, it is studied in models of ulcerative colitis, Crohn’s disease, rheumatoid arthritis, and osteoarthrosis, where corticosteroid release can reduce inflammation.

3. Neuroendocrine Regulation – By acting on melanocortin receptors, the compound also provides insights into the crosstalk between the endocrine and nervous systems.

4. Pharmacology of Steroidogenesis – Tetracosactide Acetate enables the examination of how synthetic ACTH analogues regulate adrenal steroid synthesis, making it critical in endocrinology and pharmacological research.

Researchers are especially interested in its receptor selectivity and potency, as this makes it a more controlled and predictable alternative to natural ACTH for experimental applications.

Side Effects (For Reference in Models)

In preclinical and laboratory settings, models using Tetracosactide Acetate have reported responses similar to those seen with natural ACTH stimulation. Observed effects may include:

• Elevated cortisol and aldosterone levels

• Changes in blood pressure (hypertension in some models)

• Altered glucose metabolism

• Potential electrolyte imbalances (sodium retention, potassium excretion)

• Local irritation at the site of administration (in animal models)

• Immune modulation leading to reduced inflammation

These effects provide important insights into the therapeutic and biological impact of ACTH analogues. However, it is essential to note that Tetracosactide Acetate supplied here is strictly for laboratory research use and is not approved for clinical or human application.

Disclaimer

This product is provided exclusively for laboratory research purposes. It is not intended for human, veterinary, or therapeutic use. Researchers must handle according to GMP-grade laboratory safety protocols.

Keywords

Tetracosactide Acetate, Tetracosactrin Acetate, CAS 60189-34-6, ACTH analogue peptide, melanocortin-4 receptor agonist, MC4R agonist research, ACTH fragment 1-24, corticosteroid release research, autoimmune disease peptide, GMP peptide supplier