Description

Product Description

Tetrapeptide is a short synthetic peptide engineered as an analogue of α-Melanocyte Stimulating Hormone (α-MSH). Its structure allows it to interact with melanocortin receptors, particularly MC1R, to modulate melanogenesis and skin pigmentation pathways in experimental settings.

Laboratory studies demonstrate that Tetrapeptide stimulates melanin production while simultaneously reducing DNA damage caused by ultraviolet radiation. This dual function is achieved by lowering reactive oxygen species (ROS) generation and enhancing nucleotide excision repair mechanisms, particularly the repair of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts in DNA.

By influencing melanocyte biology, Tetrapeptide also supports the natural protective pigmentation processes without excessive oxidative stress. It has been investigated for its synergistic effects when combined with antioxidants, UV filters, or other cosmetic peptides, improving cellular resilience and pigmentation balance in cultured skin models.

Tetrapeptide exhibits efficient skin penetration due to its small size and amphiphilic properties, making it suitable for topical formulation studies such as serums, creams, or lotions. Researchers also study its role in mitigating photodamage and improving overall skin health at the cellular level.

The peptide’s high purity and reproducible bioactivity make it a reliable candidate for laboratory investigations into melanogenesis, photoprotection, oxidative stress mitigation, and DNA repair mechanisms in cosmetic science and dermatological research.

Product Specifications

Mechanism of Action

Tetrapeptide acts primarily through melanocortin receptor pathways to regulate pigmentation and protect against photodamage.

1. Melanogenesis Modulation

Tetrapeptide binds to MC1R receptors on melanocytes, promoting melanin synthesis while maintaining cellular homeostasis. It effectively balances eumelanin and pheomelanin production in in vitro models.

2. Oxidative Stress Reduction

The peptide reduces the generation of reactive oxidative species (ROS) in melanocytes and keratinocytes, preventing oxidative damage to cellular proteins, lipids, and DNA.

3. DNA Photoproduct Repair Enhancement

Tetrapeptide enhances the nucleotide excision repair system, facilitating faster and more accurate repair of UV-induced DNA photoproducts such as CPDs and 6-4 photoproducts, thereby improving cellular resilience against UV exposure.

4. Synergistic Anti-Photodamage Effects

When combined with antioxidants, UV filters, or other cosmetic peptides, Tetrapeptide demonstrates improved efficacy in protecting skin cells from UV-induced oxidative stress and DNA damage.

5. Extracellular Matrix Support

Tetrapeptide indirectly promotes fibroblast activity by reducing oxidative stress in the dermal environment, which may contribute to improved ECM integrity and skin elasticity in research studies.

Side Effects

• Cytotoxicity: Minimal in laboratory concentrations; safe under recommended experimental conditions.

• Irritation: No significant irritation observed in reconstructed human epidermal models.

• Phototoxicity: Non-phototoxic; supports cellular defense against UV-induced damage.

• Stability Considerations: Sensitive to UV light, high temperatures, and extreme pH; store at 2–8 °C protected from light.

• Experimental Guidance: Perform concentration-dependent cytotoxicity tests prior to formulation development.

Tetrapeptide is strictly for research use and is not intended for ingestion, injection, or clinical therapy.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.