Description

Product Description

Tetrapeptide-1 is a synthetic signaling peptide extensively studied in cosmetic and dermatological research for its anti-aging and skin-rejuvenating properties. Comprising a short sequence of amino acids, this peptide functions primarily by stimulating the synthesis of key extracellular matrix (ECM) proteins, including collagen, elastin, and fibronectin. These proteins are essential for maintaining skin structure, elasticity, and resilience, and their reduction is a major contributor to the visible signs of skin aging, such as fine lines, wrinkles, and sagging.

Research demonstrates that Tetrapeptide-1 enhances fibroblast activity, the primary cell type responsible for ECM protein production. By promoting fibroblast proliferation and collagen synthesis, it contributes to the restoration of dermal thickness and mechanical strength, making it a critical component in anti-aging cosmetic formulations. In addition, its antioxidant properties help mitigate oxidative stress caused by reactive oxygen species (ROS), protecting skin cells from environmental damage and photoaging induced by UV exposure.

Tetrapeptide-1 has also been shown to influence cell signaling pathways involved in tissue repair and regeneration. Its modulation of growth factors and cytokines supports skin homeostasis, reduces inflammation, and enhances the skin’s natural repair mechanisms. Moreover, by improving the integrity and density of the ECM, Tetrapeptide-1 promotes hydration retention and barrier function, reducing transepidermal water loss and enhancing overall skin smoothness and firmness.

In cosmetic applications, Tetrapeptide-1 is frequently incorporated into serums, creams, and masks designed to target aging skin, improve skin texture, and prevent the formation of wrinkles. Its ability to work synergistically with other active ingredients, such as hyaluronic acid, antioxidants, and other cosmetic peptides, further amplifies its anti-aging benefits, making it a versatile ingredient in advanced skin care formulations.

Product Specifications

Mechanism of Action

Tetrapeptide-1 acts as a signaling peptide, initiating a cascade of molecular events that enhance the production of key ECM proteins. It binds to specific receptors on fibroblasts and keratinocytes, stimulating intracellular pathways that upregulate genes associated with collagen (types I and III), elastin, and fibronectin synthesis. By enhancing ECM density and integrity, Tetrapeptide-1 strengthens the dermal framework, increases elasticity, and smooths wrinkles.

Additionally, Tetrapeptide-1 exhibits antioxidant activity by scavenging reactive oxygen species (ROS) and reducing oxidative stress in skin cells. This activity protects fibroblasts and keratinocytes from damage caused by environmental factors such as UV radiation and pollution. By reducing oxidative stress, Tetrapeptide-1 helps maintain cellular viability and prevents premature aging.

The peptide also modulates cytokine and growth factor levels, including TGF-β, VEGF, and IGF-1, which are essential for tissue repair, angiogenesis, and skin regeneration. By enhancing these signaling pathways, Tetrapeptide-1 promotes collagen deposition, supports wound healing, and increases skin resilience. Its effects on fibroblast proliferation and differentiation ensure that the ECM remains functional and robust, counteracting age-related dermal thinning.

In combination with other cosmetic peptides, antioxidants, and hydrating agents, Tetrapeptide-1 provides synergistic benefits that accelerate ECM restoration, improve skin texture, and enhance elasticity. Clinical research supports its role in reducing fine lines, softening wrinkles, and maintaining youthful skin appearance, making it a highly valuable bioactive peptide for cosmetic research and formulation.

Side Effects

Tetrapeptide-1 is generally considered safe for in vitro and ex vivo research applications. No significant cytotoxicity has been reported at concentrations typically used in cosmetic peptide studies. Minor local reactions, such as transient erythema or mild irritation, may occur in sensitive skin models, but systemic toxicity has not been observed. Proper laboratory handling, adherence to recommended concentrations, and standard biosafety protocols are advised to ensure experimental reproducibility and safety.

Potential considerations include:

• Ensure storage under recommended conditions to preserve peptide stability.

• Avoid repeated freeze-thaw cycles that may reduce bioactivity.

• Handle in compliance with laboratory safety and chemical handling guidelines.

• In cosmetic formulation studies, consider skin penetration enhancers or delivery systems to maximize efficacy.

Overall, Tetrapeptide-1 exhibits an excellent safety profile in research and cosmetic applications when used appropriately.

Keywords

Tetrapeptide-1, Cosmetic Peptide, Anti-Aging Peptide, Skin Barrier Peptide, Collagen Stimulating Peptide, Fibroblast Activator, Sensitive Skin Research, Cosmetic Raw Material, High-Purity Peptide

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Tetrapeptide-1 product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Tetrapeptide-1 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Tetrapeptide-1 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.