Description

Product Description

Tetrapeptide-21 is a synthetic tetrapeptide carefully designed for advanced cosmetic research. Comprised of four amino acids, this peptide functions as a signaling molecule that regulates cellular pathways critical for dermal homeostasis, extracellular matrix (ECM) production, and skin integrity.

In vitro studies have shown that Tetrapeptide-21 promotes fibroblast proliferation and enhances the metabolic activity of dermal cells, which are central to maintaining structural proteins such as collagen types I and III, hyaluronic acid, and fibronectin. By stimulating these key components, Tetrapeptide-21 supports dermal density, elasticity, and hydration levels, making it a valuable tool in anti-wrinkle and skin rejuvenation research.

Researchers have also explored its effect on keratinocytes and the epidermal barrier, demonstrating improved nutrient delivery, reduced oxidative stress markers, and enhanced skin barrier resilience. The peptide’s small molecular weight and amphiphilic properties allow it to penetrate the stratum corneum efficiently, ensuring delivery to target cells in the dermis without degradation during experimental topical formulations.

The multifunctional role of Tetrapeptide-21 extends beyond ECM synthesis. It has been reported to downregulate matrix metalloproteinases (MMPs), including MMP-1 and MMP-9, which are enzymes responsible for collagen degradation. By inhibiting these enzymes, Tetrapeptide-21 prolongs dermal integrity and provides long-term anti-aging benefits in controlled research environments.

Synergistic studies with other peptides, such as palmitoyl hexapeptides, acetyl tripeptides, and dipeptides, indicate that Tetrapeptide-21 enhances the performance of combination peptide formulations. Co-application with antioxidants like vitamin C, resveratrol, or niacinamide has shown potential for further improving dermal repair, reducing oxidative damage, and optimizing skin smoothness.

Laboratory findings also highlight the peptide’s ability to modulate inflammatory pathways. Tetrapeptide-21 reduces the expression of pro-inflammatory cytokines (IL-6, TNF-α) in fibroblast cultures, helping maintain a balanced microenvironment conducive to tissue regeneration and wrinkle prevention.

Its stability in aqueous and ethanol-based solutions, combined with high purity (≥99%), enables reproducible experiments across multiple laboratories, making Tetrapeptide-21 an ideal candidate for both mechanistic studies and applied formulation research.

Overall, Tetrapeptide-21 serves as a scientifically robust peptide for exploring anti-aging mechanisms, ECM restoration, fibroblast activation, and skin barrier enhancement, providing researchers with a versatile tool for cosmetic and dermatological investigations.

Product Specifications

Mechanism of Action

Tetrapeptide-21 functions through multiple molecular mechanisms that collectively enhance skin structure and reduce visible signs of aging.

1. Fibroblast Activation

Tetrapeptide-21 directly stimulates dermal fibroblasts, the primary cells responsible for ECM production. Activated fibroblasts increase proliferation, metabolic activity, and protein synthesis, contributing to enhanced dermal density and improved skin elasticity.

2. ECM Gene Upregulation

Tetrapeptide-21 upregulates the expression of genes encoding collagen I, collagen III, hyaluronic acid synthase 1, fibronectin, and elastin. This activity reinforces the dermal scaffold, improves tensile strength, and maintains structural support for overlying epidermal layers.

3. Collagen and Hyaluronic Acid Synthesis

By promoting collagen and hyaluronic acid biosynthesis, Tetrapeptide-21 increases dermal thickness, water retention, and resilience. Enhanced hydration reduces wrinkle depth, while robust collagen networks provide long-term firmness.

4. Anti-Wrinkle and Anti-Aging Effects

Tetrapeptide-21 suppresses matrix metalloproteinase activity (MMP-1, MMP-9), preventing ECM degradation and prolonging structural integrity. This anti-collagenase activity, combined with fibroblast stimulation, results in clinically relevant reductions in fine lines and wrinkles in laboratory models.

5. Anti-Inflammatory Modulation

Tetrapeptide-21 reduces pro-inflammatory cytokines (IL-6, TNF-α) and oxidative stress markers in fibroblasts. This action stabilizes the dermal microenvironment, improving cell viability and supporting regenerative processes.

6. Synergistic Activity with Other Ingredients

When combined with other peptides, antioxidants, or moisturizers, Tetrapeptide-21 exhibits additive or synergistic effects. Studies indicate improved ECM deposition, wrinkle depth reduction, and overall skin rejuvenation when formulated in multi-ingredient serums or creams.

7. Molecular Signaling Pathways

Research suggests Tetrapeptide-21 influences key signaling pathways, including TGF-β/SMAD, MAPK/ERK, and NF-κB. Modulating these pathways enhances collagen transcription, cell proliferation, and anti-inflammatory responses, making it a versatile tool for mechanistic skin research.

Side Effects

Tetrapeptide-21 has demonstrated an excellent safety profile in vitro and in controlled laboratory studies.

• Cytotoxicity: Minimal, even at higher research concentrations.

• Irritation & Sensitization: No significant irritation or sensitization reported in reconstructed human epidermal models.

• Phototoxicity: Non-phototoxic under standard light exposure conditions.

• Stability Considerations: Sensitive to prolonged heat, UV light, and extreme pH; store at 2–8 °C in sealed containers.

• Experimental Guidance: Concentration-dependent cytotoxicity assays are recommended before formulation incorporation.

Tetrapeptide-21 is intended strictly for laboratory research and is not for ingestion, injection, or direct therapeutic use. Variations in formulation, solvent, and concentration may influence observed effects.

Keywords

Tetrapeptide-21, anti-wrinkle peptide, skin elasticity peptide, dermal fibroblast activator, ECM stimulator, cosmetic peptide research, factory peptide supplier, peptide wholesale China, cosmetic raw material manufacturer, high-purity cosmetic peptides, OEM & bulk peptide production, China peptide manufacturer, lab-grade peptide, high purity.

Shipping Guarantee

All Tetrapeptide-21 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.