Description

Product Description

Tetrapeptide-26 is a short-chain synthetic peptide comprising four amino acids that form a stable bioactive sequence designed for cosmetic applications. Its primary function is to modulate dermal fibroblast activity, stimulate collagen synthesis, enhance elastin fiber production, and restore the extracellular matrix. These effects lead to visible improvements in skin texture, elasticity, and reduction of fine lines and wrinkles.

Mechanistic Insights: Tetrapeptide-26 mimics naturally occurring signaling peptides that regulate extracellular matrix homeostasis. By binding to specific receptors on fibroblasts, it activates intracellular pathways such as TGF-β, MAPK, and SMAD, leading to increased transcription of genes responsible for type I and III collagen, elastin, and glycosaminoglycans. This results in improved dermal structural integrity and skin resilience.

Cellular Effects: In vitro studies demonstrate that Tetrapeptide-26 promotes fibroblast proliferation without cytotoxic effects. It enhances keratinocyte differentiation, contributing to a stronger epidermal barrier and improved skin hydration. Additionally, Tetrapeptide-26 exhibits antioxidant properties by reducing intracellular reactive oxygen species (ROS), thereby mitigating oxidative stress-induced cellular damage.

Applications: Tetrapeptide-26 is primarily used in cosmetic research focused on anti-aging, skin firming, and wrinkle reduction. It is compatible with formulations such as facial serums, eye creams, neck treatments, and hair care products targeting scalp fibroblast activity. The peptide also synergizes with other actives such as hyaluronic acid, niacinamide, vitamin C, and other cosmetic peptides to enhance overall rejuvenation effects.

Safety Profile: Tetrapeptide-26 demonstrates minimal irritation potential and high biocompatibility. Skin patch tests and in vitro studies confirm that it is well tolerated in topical applications. Chronic exposure does not adversely affect cellular proliferation or differentiation, making it suitable for long-term cosmetic research studies.

Experimental Data: Laboratory data reveal that Tetrapeptide-26 can increase collagen type I synthesis by over 110%, enhance elastin deposition by approximately 70%, and inhibit matrix metalloproteinases (MMP-1 and MMP-3), enzymes responsible for structural protein degradation. Its antioxidant activity further protects dermal fibroblasts from UVA- and UVB-induced oxidative stress.

Conclusion: Tetrapeptide-26 is a high-purity, bioactive cosmetic peptide with a multi-modal mechanism, combining fibroblast stimulation, extracellular matrix restoration, antioxidant activity, and skin barrier enhancement. These properties make it an effective candidate for anti-aging cosmetic research.

Product Specifications

Mechanism of Action

Tetrapeptide-26 acts via multiple mechanisms to exert its anti-aging effects:

1. Fibroblast Stimulation:
   The peptide binds to dermal fibroblast receptors, activating intracellular signaling cascades (MAPK, SMAD, and TGF-β), promoting synthesis of type I and III collagen and elastin, which restores dermal structure and elasticity.

2. Matrix Metalloproteinase Inhibition:
   Tetrapeptide-26 downregulates MMP-1 and MMP-3 expression, reducing collagen and elastin degradation, which helps maintain extracellular matrix integrity and delays skin aging.

3. Antioxidant Activity:
   It mitigates oxidative stress by reducing intracellular ROS levels in fibroblasts and keratinocytes, helping prevent photoaging and environmental damage.

4. Keratinocyte Differentiation:
   The peptide promotes keratinocyte maturation, enhancing stratum corneum integrity, improving hydration, and reinforcing the skin barrier.

5. Synergistic Effects:
   When combined with hyaluronic acid, niacinamide, vitamin C, or other bioactive peptides, Tetrapeptide-26 demonstrates additive effects, improving overall skin firmness, hydration, and wrinkle reduction.

6. Hair Follicle Support:
   Emerging studies suggest Tetrapeptide-26 may stimulate dermal papilla fibroblasts, promoting hair follicle growth and scalp skin regeneration.

Overall, Tetrapeptide-26 is a multi-target peptide enhancing collagen synthesis, skin elasticity, antioxidant defense, and barrier function, making it a valuable ingredient in cosmetic anti-aging research.

Side Effects

Tetrapeptide-26 demonstrates excellent tolerability:

• Topical Use: Minimal irritation potential; safe for concentrations up to 5% in cosmetic formulations.

• Cellular Models: No cytotoxic effects observed in fibroblasts or keratinocytes.

• Allergenicity: Low allergenic potential; does not trigger histamine release in mast cells.

• Chronic Exposure: Safe in prolonged studies, showing no adverse effects on cell proliferation or differentiation.

• Comparison: Superior dermal penetration and anti-aging efficacy compared to other tetrapeptides or short-chain bioactive peptides.

Keywords

Tetrapeptide-26, bioactive peptide, cosmetic peptide, anti-aging peptide, wrinkle reduction, skin rejuvenation, collagen stimulator, elastin promoter, high purity, lyophilized powder

Shipping Guarantee

All Tetrapeptide-26 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Tetrapeptide-26 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Tetrapeptide-26 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Tetrapeptide-26 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.