描述
Product Specifications
Attribute | Details |
---|---|
Product Name | Therapeutic BCG Injection (Bisaiji®) |
Generic Name | Bacillus Calmette–Guérin (live attenuated) |
Type | Immune Stimulant / Therapeutic Vaccine |
Dosage Form | Lyophilized powder for injection |
Strength | 60?mg (6.0?×?10??CFU) per vial |
Pack Size | 2 vials per box |
Approval Number | S20123007 (China NMPA) |
Product Code | 86902060000658 |
Manufacturer | Chengdu Institute of Biological Products (CDIBP) |
Barcode | 6915797574327 |
Storage | Store at 2–8?°C; protect from moisture |
Intended Use | Laboratory research use only |
Mechanism of Action
BCG is a live attenuated vaccine that induces strong innate and adaptive immune responses. In bladder cancer, intravesical BCG recruits TH1 cells and macrophages to destroy tumor cells. It also activates trained immunity—enhancing non-specific host defenses via epigenetic reprogramming of innate immune cells.
clinicaltrials.gov+1synapse.patsnap.com+1
Research Applications & Immunotherapy
-
Bladder cancer models (NMIBC): BCG treatment reduces recurrence and progression in preclinical studies.
verywellhealth.com -
Tuberculosis vaccine research: BCG remains central to TB prevention models and immunogenicity assays.
-
Trained immunity: Used in studies showing enhanced resistance to respiratory infections, leprosy, sepsis, and possibly neuroinflammation such as Alzheimer’s.
-
Mechanistic immunotherapy studies: Explores NK cell activation, cytokine release, and epigenetic cell programming.
? Safety Profile & Handling
Adverse Effects & Precautions:
-
Common: Local erythema, mild fever, flu-like symptoms post?injection
-
Rare: Severe infection, especially in immunocompromised hosts; avoid use in pregnancy
-
Handling: Live bacterial agent—use biosafety cabinets, solution disposal with disinfectant, full PPE during preparation and administration
?? Research?Use Disclaimer
This product is strictly for laboratory research purposes. It is not intended or approved for clinical, therapeutic, diagnostic, or veterinary use. Improper handling or use may cause serious health hazards or contaminate research models.
评价
目前还没有评价