Description

Tofacitinib is a potent, selective inhibitor of Janus kinases JAK1 and JAK3, with moderate activity against JAK2. It modulates immune signaling via the JAK-STAT pathway. The Yangdu Jianhua formulation delivers 5?mg per tablet, ideal for preclinical and pharmacological research.

Manufactured by Shandong Hualu Pharmaceutical Co., Ltd. and approved by China’s NMPA (H20243208) with drug code 86981741000019 and barcode 6977302650025.

?? For laboratory research use only. Not intended for clinical or veterinary application.

Product Specifications

Mechanism & Research Applications

Tofacitinib competitively inhibits ATP binding at the catalytic site of JAK1/JAK3 and partially JAK2, thereby blocking downstream STAT activation and immune signaling. Common lab applications include:

• In vitro and in vivo immune signaling studies

• Cytokine secretion modulation assays

• Preclinical autoimmune and inflammation models

• Comparative analysis with other JAK inhibitors

• Pharmacokinetics and pharmacodynamics research

Side Effects (Observed in Research Context)

Lab-based or animal studies indicate possible effects including:

• Transient lymphocyte or neutrophil reduction

• Mild elevations in liver enzymes

• Inflammation or gastrointestinal discomfort

• Suppressed immune response and increased infection markers

• Altered lipid levels in long-term dosing

Proper safety protocols are required during in vivo usage.

Safety & Handling

• Use Restriction: Only for laboratory research. Not for clinical, therapeutic, or veterinary use

• PPE Required: Gloves, lab coat, eye protection

• Storage: Store sealed between 20–25?°C, avoid light

• Disposal: Dispose of according to institutional chemical safety protocols

Core Keywords

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Research Use Disclaimer

This product is strictly for laboratory research purposes. It is not approved for therapeutic, diagnostic, clinical, or veterinary use. Misuse may pose safety or regulatory violations. Always follow institutional biosafety and handling protocols.