Description

Product Description

Tripeptide-10 Citrulline (CAS 960531-53-7) is a bioactive synthetic peptide that plays a significant role in regulating collagen fiber organization and improving the extracellular matrix architecture. Known for its biomimetic properties, it is often referred to as a “collagen equalizer” due to its ability to normalize collagen fibril diameter and spacing. This regulatory function helps maintain the optimal density and structure of the dermal network, which directly contributes to skin elasticity, smoothness, and firmness — key factors in anti-aging research.

The peptide is composed of a tripeptide linked to citrulline, a non-essential amino acid involved in nitrogen metabolism and protein synthesis. This unique structure allows Tripeptide-10 Citrulline to interact effectively with glycosaminoglycans (GAGs) and proteoglycans, such as decorin and lumican, which are essential regulators of collagen fiber assembly. By mimicking the natural mechanisms of decorin, Tripeptide-10 Citrulline helps ensure that collagen fibers form in a uniform, organized manner, preventing the irregular thickening that contributes to skin stiffness and loss of elasticity with aging.

In vitro research has demonstrated that Tripeptide-10 Citrulline enhances fibroblast activity and supports the synthesis of collagen types I and III, while maintaining proper fibril size. It also improves cell-to-matrix interactions, leading to increased dermal density and elasticity. Furthermore, Tripeptide-10 Citrulline contributes to hydration and resilience by stabilizing the skin’s structural proteins and preventing enzymatic degradation induced by oxidative stress.

When incorporated into cosmetic or research formulations, Tripeptide-10 Citrulline enhances the biomechanical properties of the skin model, making it appear smoother and more supple. It works synergistically with other peptides such as Tripeptide-1, Palmitoyl Tetrapeptide-7, and Acetyl Hexapeptide-8, offering a multi-targeted approach for anti-aging and tissue-repair studies. Its low molecular weight ensures excellent solubility and penetration into the dermal matrix, improving efficacy in peptide delivery systems.

From a molecular biology standpoint, the peptide functions through modulation of TGF-β and MMP (matrix metalloproteinase) pathways, balancing collagen synthesis and degradation. This results in reduced wrinkle depth and improved dermal elasticity. Due to its biomimetic design and compatibility with various formulation systems, Tripeptide-10 Citrulline has become a key focus in advanced anti-aging peptide research and high-purity cosmetic peptide development.

Product Specifications

Mechanism of Action

Tripeptide-10 Citrulline mimics the action of decorin, a natural proteoglycan that binds to collagen fibrils and regulates their formation. This peptide ensures proper collagen fiber organization, maintaining uniform fibril diameter and consistent spacing, which are vital for optimal dermal elasticity and skin texture.

By interacting with structural components such as glycosaminoglycans, Tripeptide-10 Citrulline normalizes collagen network structure and strengthens the extracellular matrix. It enhances fibroblast communication, promoting collagen I and III synthesis, and helps reduce the formation of disorganized collagen bundles associated with aging and photoaging.

The peptide’s mechanism also involves modulation of TGF-β and inhibition of matrix metalloproteinases (MMPs), thereby reducing collagen breakdown. Additionally, it contributes to increased skin resilience by stabilizing the ECM and protecting against oxidative and mechanical stress. This makes it a valuable ingredient in peptide-based anti-aging and dermal repair formulations.

Side Effects

In laboratory research, Tripeptide-10 Citrulline shows excellent stability and safety. It does not exhibit cytotoxic or irritant effects at experimental concentrations. It is intended strictly for in vitro or ex vivo research and should not be applied to humans or animals.

Keywords

Tripeptide-10 Citrulline, CAS 960531-53-7, collagen regulation peptide, anti-aging cosmetic peptide, extracellular matrix modulator, factory peptide supplier, peptide wholesale China, high-purity peptide manufacturer, low-price peptide supplier, OEM peptide production

Shipping Guarantee

All Tripeptide-10 Citrulline shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Tripeptide-10 Citrulline product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

Tripeptide-10 Citrulline We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Tripeptide-10 Citrulline products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.