Description

Product Description

Tripeptide-32 is a biofunctional peptide that has become an innovative model in the study of circadian rhythm regulation and cellular repair in skin biology. Designed to mimic endogenous communication peptides that align the natural day-night cycles of skin cells, Tripeptide-32 plays a central role in restoring balance between DNA protection during the day and cellular regeneration during the night.

At a molecular level, Tripeptide-32 acts as a modulator of the PER1 gene, a master regulator of the circadian clock mechanism in skin fibroblasts and keratinocytes. This gene governs numerous physiological processes, including DNA replication timing, energy metabolism, and cell cycle synchronization. By re-establishing the rhythm of PER1 expression, Tripeptide-32 helps maintain a functional cellular “biological clock”, ensuring optimal repair and renewal cycles are maintained throughout 24-hour periods.

In cosmetic and dermatological research, Tripeptide-32 is widely studied for its anti-aging and chronobiological effects. Skin cells exhibit diurnal variations in their biological activity — protection against oxidative stress during the day, and intensive repair at night. Environmental stressors such as UV light, pollution, and lack of sleep disturb this balance, accelerating signs of aging. Tripeptide-32 helps correct these disruptions by reinforcing time-dependent repair signaling, thereby enhancing resilience and visible smoothness of the skin.

Studies have shown that Tripeptide-32 enhances night-time cellular regeneration, upregulates DNA damage response (DDR) enzymes, and boosts protein synthesis related to cell cohesion and hydration. It is also known to increase cellular energy levels (ATP), thereby revitalizing fatigued cells and supporting the recovery of barrier function.

Tripeptide-32’s dual function — circadian synchronization and anti-aging support — makes it a cornerstone in chronocosmetic research, a rapidly emerging field investigating how biological rhythms affect skin health and appearance.

In research formulations, Tripeptide-32 is often used in combination with Niacinamide, Hyaluronic Acid, or Palmitoyl Peptides to amplify antioxidant capacity and moisture retention. It complements these actives by ensuring skin cells repair efficiently while maintaining homeostasis throughout the day-night cycle.

Due to its high purity (≥99%), excellent solubility, and strong stability, Tripeptide-32 is an ideal candidate for advanced skin rejuvenation, circadian rhythm correction, and cell regeneration research applications.

Product Specifications

Mechanism of Action

Tripeptide-32 functions through its ability to regulate circadian gene expression within skin cells, specifically targeting the PER1 gene — one of the core circadian regulators in mammalian systems. The PER1 gene operates within a molecular feedback loop that coordinates DNA repair, antioxidant defense, and energy metabolism in time with the 24-hour cycle.

Disruptions to circadian homeostasis, such as through UV exposure or irregular sleep cycles, have been linked to premature skin aging, barrier impairment, and reduced DNA integrity. Tripeptide-32 counteracts these effects by realigning the timing of PER1 activation, thus optimizing repair during night hours and protection during daylight exposure.

Mechanistically, the peptide interacts with cellular transcription factors, enhancing PER1 mRNA expression during nocturnal phases. This upregulation triggers downstream repair cascades, including increased synthesis of cellular chaperone proteins, DNA repair enzymes, and antioxidant molecules.

Simultaneously, Tripeptide-32 helps suppress inflammatory mediators and limit ROS accumulation, two major contributors to oxidative aging. By doing so, it not only accelerates recovery from daytime oxidative damage but also extends the skin’s youthful functionality.

At the biochemical level, Tripeptide-32 boosts cellular communication between keratinocytes and fibroblasts, maintaining a synchronized rhythm of collagen and elastin production. This synchronization contributes to improved dermal structure, enhanced hydration, and reduced wrinkle depth in long-term studies.

Furthermore, the peptide increases mitochondrial efficiency by promoting NAD⁺ balance and ATP synthesis. Enhanced mitochondrial performance ensures consistent cellular energy throughout circadian phases, preventing premature cell fatigue and supporting skin barrier restoration.

In chronobiology-inspired formulations, Tripeptide-32 acts as a key regulator that brings temporal precision to anti-aging research — ensuring that protective mechanisms are active when needed and that repair processes occur efficiently during the skin’s nocturnal recovery phase.

Side Effects

Tripeptide-32 has demonstrated excellent tolerability and non-irritating properties in vitro and ex vivo skin models. It shows no cytotoxic or sensitizing behavior within the tested research concentration ranges.

Due to its short-chain, naturally inspired amino acid composition, Tripeptide-32 exhibits high biocompatibility and stability. Researchers are advised to store it under standard peptide preservation conditions (below -20°C, away from moisture) to prevent hydrolytic degradation.

As with all laboratory-use materials, Tripeptide-32 should not be applied directly to human or animal subjects. Standard safety procedures — including the use of gloves, masks, and goggles — should be followed when handling.

Keywords

Tripeptide-32, CAS 1185583-20-3, PER1 gene peptide, circadian rhythm peptide, anti-aging peptide, cellular repair peptide, chronobiology research peptide, skin rejuvenation peptide, cosmetic peptide manufacturer China, high-purity cosmetic peptides, factory peptide supplier, low-price peptide wholesale, OEM peptide production, cosmetic raw material supplier

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.