描述
Vapreotide is a synthetic octapeptide analog of somatostatin, featuring a cyclic disulfide bridge. It mimics somatostatin’s biological actions, including hormone secretion inhibition, gastrointestinal regulation, and tumor angiogenesis suppression. Clinically, it has been used to control esophageal variceal bleeding in cirrhotic patients and studied for its gastrointestinal motility effects. Current research explores its immunomodulatory, anti-inflammatory, and potential anti-cancer activities. Manufactured to GMP standards with ? 99.87% purity.
Product Specifications
| Parameter |
Details |
| Product Name |
Vapreotide |
| Synonyms |
Octastatin; H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH? |
| CAS No. |
103222-11-3 |
| Purity |
? 99.87% (GMP-grade) |
| Molecular Formula |
C??H??N??O?S? |
| Molecular Weight |
~1131 Da |
| Sequence |
H-D-Phe-Cys(2)-Tyr-D-Trp-Lys-Val-Cys(7)-Trp-NH? |
| Appearance |
White to off-white powder |
| Solubility |
Soluble in water and DMSO |
| Storage Conditions |
Store at –20 °C; protect from light and moisture |
| Manufacturing Standard |
GMP-compliant |
| Applications |
Research on gastrointestinal regulation, angiogenesis, inflammation |
| Regulatory Status |
For laboratory research use only |
Mechanism of Action & Research Applications
Vapreotide functions as a somatostatin analog that binds to somatostatin receptors, inhibiting hormone release and gastrointestinal motility. It effectively controls variceal bleeding by reducing portal pressure and blood flow. Research indicates it may also exert anti-angiogenic, anti-inflammatory, and immunomodulatory effects, making it valuable for studies on gut function, tumor biology, and immune responses.
Disclaimer
This product is intended strictly for laboratory research use only. It is not approved for human or veterinary use. Please adhere to institutional safety protocols when handling.
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