Description
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Vardenafil Hydrochloride Tablets (Guan’ai® / Qing Doctor) |
| Generic Name | Vardenafil Hydrochloride |
| CAS Number | 224785?90?4 (free base) / 330808?88?3 (HCl trihydrate) access.portico.org+12en.wikipedia.org+12accessdata.fda.gov+12 |
| Molecular Formula | C??H??N?O?S · HCl · 3H?O (trihydrate) |
| Molecular Weight | ~579.1?g/mol (trihydrate) |
| Dosage Form | Film-coated oral tablet |
| Strength | 20?mg per tablet |
| Pack Size | 5 tablets per box (1 blister pack) |
| Approval No. | China NMPA H20244792 |
| Product Code | 86904339000956 |
| Manufacturer | Anhui Pioneer Pharmaceutical Co., Ltd. |
| Barcode | 6953780000446 |
| Storage | Store at 15–25?°C; protect from light and moisture |
| Intended Use | Laboratory/preclinical research only |
Mechanism of Action
Vardenafil selectively inhibits PDE5, preventing cGMP breakdown and amplifying nitric oxide-mediated smooth muscle relaxation—primarily in penile and vascular tissues .
Research Applications & Pharmacology
Erectile Dysfunction & Andrology Models: Extensively utilized in PDE5-targeting studies focused on sexual function and vascular physiology .
Cardiovascular & Pulmonary Research: Enables exploration of vasodilatory response and pulmonary hypertension .
Pharmacokinetics: Oral bioavailability ~15%; protein binding ?95%; liver metabolism via CYP3A4; half-life of 4–5?h .
Toxicology: Non-carcinogenic up to 100 mg/kg/day in animals; high-dose exposures induced testicular and cardiovascular changes in rodents .
Safety Profile & Handling
Common Effects: Headache, flushing, nasal congestion, back pain, dizziness.
Serious Risks: Rare hypotension (especially with nitrates), QT prolongation, priapism .
Drug Interactions / Contraindications: Avoid co-administration with nitrates, alpha-blockers, or strong CYP3A4 inhibitors in research protocols .
Handling Instructions: Use PPE, store under recommended conditions, discard expired tablets per lab safety guidelines.


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