Vensemaglutide | CAS No. 2919344-88-8

Description

Product Description

Vensemaglutide (CAS 2919344-88-8) is a synthetic peptide designed to act as a potent agonist for the GLP-1 receptor, a key regulator of glucose metabolism, insulin secretion, and appetite. GLP-1 receptor agonists like Vensemaglutide have been widely studied for their ability to enhance glucose-dependent insulin secretion, slow gastric emptying, and reduce food intake, making them critical tools in the study of diabetes, obesity, and other metabolic disorders.

Background and Origin

The glucagon-like peptide 1 (GLP-1) is an incretin hormone naturally secreted by the intestinal L-cells in response to nutrient intake. GLP-1 receptor agonists mimic the physiological action of endogenous GLP-1 but have enhanced stability and prolonged half-life, allowing researchers to study metabolic regulation in vitro and in vivo. Vensemaglutide was developed as a long-acting GLP-1 receptor agonist with high receptor affinity, enabling precise experimental control in metabolic research models.

Pharmacological Relevance

Vensemaglutide activates GLP-1 receptors on pancreatic β-cells, enhancing insulin secretion in a glucose-dependent manner. This mechanism reduces the risk of hypoglycemia in experimental settings. Additionally, GLP-1 receptor activation in the central nervous system regulates appetite and body weight, providing a multi-system approach for metabolic research.

Research Applications

• Diabetes Research – Studies involving insulin secretion, glucose homeostasis, and pancreatic β-cell function.

• Obesity and Weight Management Studies – GLP-1 receptor agonists like Vensemaglutide reduce food intake and promote satiety.

• Metabolic Syndrome Research – Investigating effects on lipid metabolism, energy balance, and cardiovascular risk.

• Pharmacological Studies – Preclinical assessment of GLP-1 analog pharmacokinetics and receptor binding properties.

Through its high receptor selectivity and stability, Vensemaglutide continues to be a valuable tool in endocrinology and metabolic disease research.

Product Specifications

Extended Specification Notes

• High Purity Assurance: HPLC verified for reproducible research results.

• Storage and Stability: Suitable for long-term experiments.

• Application Spectrum: Primarily for metabolic and endocrinology research.

Mechanism of Action

Vensemaglutide acts as a GLP-1 receptor agonist, modulating multiple pathways involved in glucose and energy homeostasis:

• Glucose-Dependent Insulin Secretion
  Activates pancreatic β-cells to enhance insulin release only when glucose levels are elevated, reducing hypoglycemia risk.

• Appetite Regulation
  Acts on the central nervous system to promote satiety and reduce food intake, supporting obesity research.

• Gastric Emptying Delay
  Slows nutrient absorption to improve postprandial glucose control.

• Multi-Organ Effects
  Influences cardiovascular function, liver metabolism, and adipose tissue regulation in preclinical models.

Vensemaglutide provides a comprehensive metabolic modulation model, essential for diabetes, obesity, and metabolic syndrome studies.

Side Effects

Preclinical Safety Profile

• Low Toxicity: Animal studies report minimal adverse effects at experimental doses.

• Specificity: Acts specifically on GLP-1 receptors with minimal off-target activity.

Potential Risks in Research Use

• Gastrointestinal Effects: May induce transient nausea or delayed gastric emptying in animal models.

• Hypoglycemia: Rare, since GLP-1 receptor agonists act in a glucose-dependent manner.

• Allergic Reactions: Theoretical risk exists for hypersensitivity in experimental animals.

Future Clinical Considerations
Further studies are needed to explore long-term effects on pancreatic β-cell function and systemic metabolism in translational research.

Disclaimer

All information is provided for research and laboratory purposes only. Vensemaglutide is not approved for human use, medical treatment, or diagnostic applications.

Keywords

Vensemaglutide peptide, CAS 2919344-88-8, GLP-1 receptor agonist, diabetes research peptide, obesity research peptide, metabolic disorder research, synthetic peptide, laboratory research peptide.

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