Vinorelbine 30?mg – NAVELBINE
$1.00
Vinorelbine (brand: NAVELBINE®) is a semi-synthetic vinca alkaloid antineoplastic agent that inhibits microtubule assembly, used in preclinical research for breast, non-small cell lung cancer (NSCLC), and brain metastasis models. This soft-gel capsule contains 30?mg. Manufactured by FAREVA PAU (France), approved in China under NMPA HJ20140658 (product code?86978754000150).
?? For laboratory research use only.?Please consult the staff for other purposes?
描述
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Vinorelbine Soft Capsule (NAVELBINE®) |
| Generic Name | Vinorelbine (semi-synthetic vinca alkaloid) |
| CAS Number | 71486?22?1 |
| Molecular Formula | C??H??N?O? |
| Molecular Weight | ~823?Da (tartrate salt ~912?Da) |
| Dosage Form | Oral soft capsule |
| Strength | 30?mg per capsule |
| Pack Size | 1 capsule per box |
| Approval Number | HJ20140658 (China NMPA) |
| Product Code | 86978754000150 |
| Manufacturer | FAREVA PAU (France) |
| Storage | Store at 20–25?°C; protect from moisture & light |
| Intended Use | Laboratory research use only |
Mechanism of Action
Vinorelbine binds to tubulin and prevents microtubule polymerization, disrupting mitotic spindle formation and arresting cells in M-phase, leading to apoptosis. It also induces cell death during interphase, especially in APC-deficient cells.
Research Applications & Pharmacology
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Preclinical oncology: Effective in breast cancer, NSCLC, ovarian, melanoma, and brain metastasis models. Oral and IV forms frequently used.
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Brain penetration studies: Demonstrates restricted brain tumor penetration, useful for evaluating blood–brain barrier dynamics.
pmc.ncbi.nlm.nih.gov -
Pharmacokinetics (oral): Bioavailability ~43%; protein binding 79–91%; metabolized via CYP3A4; half-life ~27–44?hrs; excreted fecally (~46%) and renally (~18%).
en.wikipedia.org+1zh.wikipedia.org+1
Safety Profile & Key Precautions
Observed effects:
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Hematologic: Neutropenia (dose-limiting), occasional anemia, rare thrombocytopenia
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Other: Injection-site pain, fatigue, nausea, diarrhea, peripheral neuropathy (milder than other vinca alkaloids), rare respiratory effect Lab handling:
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Monitor blood cell counts in vivo models
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Use PPE; prepare in biosafety cabinets
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Manage neuropathy/endpoints in animal studies
?? Research?Use Disclaimer
This product is intended exclusively for laboratory research. It is not approved for clinical, diagnostic, therapeutic, or veterinary applications. Misuse may pose safety risks and invalidate research results.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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