描述
Isosulfan Blue Injection Product Specifications
Parameter | Details |
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Product Name | Isosulfan Blue Injection (Bolinlan®) |
Generic Name | Isosulfan Blue |
Synonyms | Lymphazurin, Isosulfan Blue Dye, Sulfan Blue, Patent Blue V, Sulfan Blue 0.5% |
CAS Number | 68238-36-8 |
Formulation | Injectable dye solution |
Strength | 50?mg in 5?mL |
Pack Size | 1 vial per box |
Dosage Form | Injection (IV/subcutaneous, for research use) |
Approval Number | NMPA China: H20243183 |
Product Code | 86900198000731 |
Manufacturer | Guangdong Xinghao Pharmaceutical Co., Ltd. |
Barcode | 6922274450166 |
Storage | Store at 20–25?°C, protect from light |
Intended Use | Laboratory research only |
Isosulfan Blue Injection Mechanism of Action
Isosulfan Blue is a lymphatic tracer dye that selectively stains lymphatic vessels and nodes, enabling visual mapping during experimental surgeries for tumor metastasis or lymphatic function studies.
Research Applications & Pharmacology
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Widely used in sentinel lymph node mapping for research on breast, gastric, thyroid, and other solid tumors .
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Approved in China in February 2024 as the first domestic generic lymphatic tracer .
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Clinical data show >94% sentinel node identification rate, ~98% lymphatic vessel detection, with no severe dye?related toxicity bydrug.pharmcube.com.
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Minimal systemic absorption; most injected dye remains localized in lymphatics.
Safety Profile & Handling
Reported Adverse Reactions
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Skin reactions (rash, urticaria) in ?1.5% of surgical cases
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Rare but possibly life?threatening hypotension in ~0.75% static.nfapp.southcn.com+2pubmed.ncbi.nlm.nih.gov+2zh.wikipedia.org+2
Handling & Precautions
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Use standard lab PPE (gloves, mask, protective eyewear)
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Have antihistamines and emergency medications (e.g., epinephrine) on hand
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Inject slowly and monitor hemodynamics
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Dispose of dye and biohazard waste according to institutional protocols
?? Research Use Disclaimer
This product is intended exclusively for laboratory research and surgical mapping applications. Not authorized for therapeutic, veterinary, or diagnostic uses. Misuse can pose serious health and regulatory risks.
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