Tirzepatide GLP-1 GIP dual agonist

描述

Introduction

In the evolving landscape of metabolic disorder treatments, Tirzepatide has emerged as a groundbreaking therapy. As a dual agonist of the Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP) receptors, Tirzepatide offers a novel mechanism of action that addresses both glycemic control and weight management. This article delves into the pharmacological parameters, therapeutic uses, and procurement options for Tirzepatide, providing valuable insights for healthcare professionals, researchers, and bulk purchasers seeking raw material at factory low prices and discount wholesale options.

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Pharmacological Parameters of Tirzepatide

Understanding the pharmacokinetics and pharmacodynamics of Tirzepatide is crucial for its effective application in clinical settings.

Molecular Structure and Composition

Tirzepatide is a synthetic 39-amino acid peptide that combines the sequences of GIP and GLP-1, modified with a C20 fatty diacid moiety. This structural modification enhances its stability and prolongs its half-life, allowing for once-weekly dosing.

Receptor Binding Affinity

• GIP Receptor (GIPR): Tirzepatide exhibits high affinity with a Ki of 0.135 nM.

• GLP-1 Receptor (GLP-1R): It has a moderate affinity with a Ki of 4.23 nM.

Pharmacokinetics

• Bioavailability: Approximately 80% following subcutaneous administration.

• Half-Life: Approximately 5 days, supporting once-weekly dosing.

• Time to Peak Concentration (Tmax): 8 to 72 hours post-dose.

• Volume of Distribution (Vz/F): Approximately 9.5 liters.

• Clearance (CL/F): 0.056 L/h.

• Metabolism: Primarily through proteolytic cleavage and ?-oxidation.

• Excretion: Eliminated via urine and feces.

Mechanism of Action

Tirzepatide’s dual agonism of GIP and GLP-1 receptors results in synergistic effects on insulin secretion and appetite regulation.

• Insulin Secretion: Enhances glucose-dependent insulin secretion from pancreatic ?-cells.

• Glucagon Suppression: Reduces glucagon levels, decreasing hepatic glucose production.

• Gastric Emptying: Delays gastric emptying, contributing to reduced postprandial glucose spikes.

• Appetite Regulation: Promotes satiety and reduces food intake, aiding in weight loss.

Therapeutic Uses

Type 2 Diabetes Mellitus

Tirzepatide is approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. Clinical trials have demonstrated significant reductions in HbA1c levels, outperforming other GLP-1 receptor agonists.

Obesity and Weight Management

Beyond glycemic control, Tirzepatide has shown substantial efficacy in promoting weight loss in individuals with obesity or overweight conditions, making it a valuable option for chronic weight management.

Obstructive Sleep Apnea

Recent approvals have extended Tirzepatide’s indications to include the treatment of moderate-to-severe obstructive sleep apnea in adults with obesity, highlighting its multifaceted therapeutic potential.

Procurement: Raw Material, Factory Low Price, and Discount Wholesale Options

For researchers, compounding pharmacies, and bulk purchasers, sourcing Tirzepatide as a raw material offers cost-effective solutions.

Raw Material Availability

Tirzepatide is available in high-purity powder form, suitable for research and formulation purposes. Ensuring the procurement of pharmaceutical-grade material is essential for quality and efficacy.

Factory Low Price

Purchasing directly from manufacturers can significantly reduce costs. Engaging with factories that offer competitive pricing structures ensures affordability without compromising quality.

Discount Wholesale

Bulk purchasing options often come with tiered discount structures. Establishing relationships with suppliers who provide discount wholesale rates can lead to substantial savings, especially for large-scale operations.

Quality Assurance

When sourcing Tirzepatide, it’s imperative to verify:

• Certificates of Analysis (CoA): Confirming the purity and composition.

• Good Manufacturing Practices (GMP) Compliance: Ensuring adherence to quality standards.

• Supply Chain Transparency: Understanding the origin and handling of the material.

  

Conclusion

Tirzepatide represents a significant advancement in the treatment of type 2 diabetes and obesity, offering dual receptor agonism that translates into superior clinical outcomes. For stakeholders interested in procurement, understanding the pharmacological profile and sourcing options is crucial. By leveraging factory low price and discount wholesale opportunities, it’s possible to access high-quality Tirzepatide raw material, facilitating research and therapeutic applications.