Palonosetron Hydrochloride Injection 0.075?mg – 5-HT? Antagonist for CINV Research Price comparison
$2.00
Palonosetron Hydrochloride Injection (Kostin®) is a sterile 5?HT? receptor antagonist used to prevent chemotherapy-induced nausea and vomiting (CINV). Supplied as 0.075?mg in 1.5?mL per vial (10 vials per box), manufactured by Hunan Kelun Pharmaceutical Co., Ltd. Approved by China’s NMPA (H20223448; Code 86904948001313; barcode 6942746533395). Strictly for laboratory research use?Please consult the staff for other purposes?
描述
Palonosetron Hydrochloride Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Palonosetron Hydrochloride Injection (Kostin®) |
| Generic Name | Palonosetron Hydrochloride |
| Dosage Form | Sterile Injection |
| Strength | 0.075?mg per 1.5?mL vial |
| Pack Size | 10 vials per box |
| Approval Number | China NMPA H20223448 |
| Product Code | 86904948001313 |
| Manufacturer | Hunan Kelun Pharmaceutical Co., Ltd. |
| Barcode | 6942746533395 |
| Mechanism Class | Second-generation 5?HT? receptor antagonist |
| Intended Use | Laboratory research only — Not for clinical or veterinary use |
Palonosetron Hydrochloride Mechanism of Action
Palonosetron is a second-generation serotonin (5?HT?) receptor antagonist with allosteric binding and positive cooperativity, leading to stronger and longer-lasting CINV prevention compared to first-generation agents.
pmc.ncbi.nlm.nih.gov
Research & Pharmacology Insights
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Highly effective in preventing both acute and delayed phases of chemotherapy-induced nausea and vomiting, with superior delayed-CINV control compared to granisetron 3?mg IV.
dailymed.nlm.nih.gov+8pmc.ncbi.nlm.nih.gov+8annalsofoncology.org+8 -
Long half-life (~40–50?hours) enables once-per-cycle dosing.
reference.medscape.com+4en.wikipedia.org+4en.wikipedia.org+4 -
Approved for use in adults and children aged ?1 month.
Research Applications
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CINV models: Test acute vs delayed-phase efficacy
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Comparative pharmacology: Evaluate against first-generation 5?HT? antagonists
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Receptor binding assays: Study allosteric vs competitive inhibition
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PK/PD investigations: Benefit from long half-life and high affinity
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Cellular signaling research: Examine downstream effects of 5?HT? blockade
?? Research?Use Disclaimer
This product is for laboratory research and development use only. Not intended for clinical, diagnostic, therapeutic, or veterinary use.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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