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Ubenimex | CAS 58970-76-6 | Aminopeptidase Inhibitor for Preclinical Immunology and Cancer Research
Original price was: $6.00.$3.00Current price is: $3.00.
Ubenimex (CAS 58970-76-6) is a high-purity aminopeptidase inhibitor supplied as lyophilized powder for preclinical research. It is used to study immune modulation, apoptosis induction, tumor microenvironment regulation, and cytotoxicity mechanisms in cellular and molecular oncology and immunology models.
Description
Product Description
Ubenimex (bestatin), CAS 58970-76-6, is a potent and selective inhibitor of aminopeptidases such as leukotriene A4 hydrolase (LTA4H) and aminopeptidase N (CD13). These enzymes play critical roles in immune cell regulation, antigen processing, angiogenesis, and tumor proliferation. Ubenimex has been widely used in preclinical studies to investigate its dual functions: enhancing immune-mediated tumor suppression and directly inhibiting tumor cell proliferation.
As a lyophilized powder, Ubenimex provides excellent stability and precise dosing, allowing researchers to formulate solutions for in vitro and in vivo studies. Its high purity ensures consistent experimental reproducibility in studies of immune modulation, apoptosis, and cytotoxicity.
Chemical and Structural Features
Ubenimex is a small molecule with the molecular formula C14H26N2O3 and a molecular weight of 258.36 g/mol. Structurally, it is a dipeptide analog that mimics natural substrates of aminopeptidases, binding to their active sites and inhibiting enzymatic activity. This selective inhibition affects both immune and cancer cells, making it a valuable preclinical tool for studying tumor immunity and pharmacological modulation of aminopeptidases.
Pharmacological Significance
Ubenimex exerts multifaceted effects in preclinical models:
Immune Modulation: Enhances cytotoxic T-cell and natural killer (NK) cell activity by inhibiting CD13 and other immunosuppressive aminopeptidases.
Tumor Growth Inhibition: Suppresses proliferation in various tumor cell lines via aminopeptidase blockade and apoptotic pathway activation.
Apoptosis Induction: Triggers intrinsic and extrinsic apoptotic pathways in cancer cells, including caspase activation and mitochondrial depolarization.
Microenvironment Regulation: Modulates tumor angiogenesis, extracellular matrix remodeling, and immune cell infiltration.
Ubenimex is particularly suitable for studies in hematologic malignancies, solid tumors, and models of tumor immunotherapy, providing a dual mechanism to investigate both immune enhancement and direct tumor suppression.
Preclinical Applications
Immune Response Studies: Analyze T-cell, NK-cell activity, and dendritic cell function in vitro and in vivo.
Cancer Research: Evaluate cytotoxicity, apoptosis, and tumor growth suppression in preclinical models.
Combination Therapy Research: Study synergistic or antagonistic effects with chemotherapeutics, checkpoint inhibitors, or kinase inhibitors.
Mechanism of Resistance Studies: Explore resistance mechanisms via aminopeptidase expression changes or immune escape pathways.
Pharmacodynamic and Pharmacokinetic Evaluations: Lyophilized powder allows precise reconstitution for dosing in animal models.
Ubenimex
Product Specifications
| Parameter | Specification / Data |
|---|---|
| Chemical Name / Synonyms | Ubenimex; Bestatin; C14H26N2O3 |
| CAS Number | 58970-76-6 |
| Molecular Formula | C14H26N2O3 |
| Molecular Weight | 258.36 g/mol |
| Purity / Assay | ≥99% |
| Appearance | White to off-white lyophilized powder |
| Dosage Form | Lyophilized powder for research use |
| Solubility | Soluble in water, DMSO, or laboratory-grade buffers |
| Concentration | Typically 1–10 mM solutions for in vitro assays |
| Storage Temperature | 2–8 °C; protect from light and moisture |
| Stability | Stable under refrigeration; avoid repeated freeze-thaw cycles |
| Analytical Methods | HPLC, MS, NMR verified; batch consistency confirmed |
| Mechanistic Target | Aminopeptidases (CD13, LTA4H), immune modulation, apoptosis induction |
| Structural Category | Dipeptide analog, aminopeptidase inhibitor |
| Applications | Preclinical immunology studies, tumor cytotoxicity, apoptosis research, combination therapy, drug resistance modeling |
| Batch Consistency | Verified by HPLC, MS, NMR |
| Regulatory Notes | For laboratory research use only |
| Origin | Factory small-molecule supplier, China chemical manufacturer, OEM & bulk production available |
| Additional Data | SMILES: CC(C)C(C(=O)NC@@HC(=O)O)NC(C)C; CoA provided for each batch |
Mechanism of Action
Aminopeptidase Inhibition
Ubenimex selectively binds to active sites of aminopeptidases, preventing peptide substrate cleavage. Key effects include:
CD13 (Aminopeptidase N) Inhibition: Reduces tumor cell invasion, angiogenesis, and proliferation.
LTA4H Inhibition: Modulates leukotriene metabolism and inflammatory responses in immune cells.
Immune Enhancement
Enhances T-cell cytotoxicity and NK-cell activity
Modulates antigen presentation and cytokine release
Reduces immunosuppressive signaling within the tumor microenvironment
Apoptosis Induction
Mitochondrial depolarization and cytochrome c release
Caspase-3 and caspase-9 activation
ROS generation contributing to cytotoxic stress
G1/S cell-cycle arrest in tumor cells
Preclinical Research Applications
Mechanistic studies in immune-oncology models
Combination therapy with chemotherapeutics or immunomodulators
Resistance mechanism exploration in cancer and immune cells
Ubenimex Side Effects (Preclinical Observations)
Cellular Effects
Reduced proliferation in tumor cells
G1/S phase cell-cycle arrest
ROS-mediated cytotoxic stress
Modulation of immune cell activity
Apoptotic Effects
Activation of intrinsic apoptosis pathways via caspase cascade
Mitochondrial depolarization and cytochrome c release
p53-dependent and independent cell death
Laboratory Handling
Use appropriate PPE and fume hood
Store at 2–8 °C, protected from light and moisture
Avoid repeated freeze-thaw cycles
Handle strictly as cytotoxic research reagent
Keywords
Ubenimex, Bestatin, aminopeptidase inhibitor, CD13 inhibitor, LTA4H inhibitor, immune modulation research, apoptosis studies, tumor cytotoxicity, preclinical immunology, cancer microenvironment research, combination therapy studies, high-purity research chemical, factory small-molecule supplier, China chemical manufacturer, OEM & bulk production, laboratory research reagent
Shipping Guarantee
All Ubenimex shipments of Ubenimex lyophilized powder are handled using validated cold-chain logistics to maintain compound stability. Packages are sealed with protective wrapping and shipped via express international couriers with tracking and insurance. Conditions are monitored to preserve the integrity of the powder during transit.
Trade Assurance
We guarantee the authenticity and quality of all Ubenimex batches. Purity is verified at ≥99% via HPLC, MS, and NMR. Certificates of Analysis (CoA) are provided for each batch. Replacement or refund is assured for any deviation from listed specifications.
Payment Support
Flexible global payment options include:
PayPal
Major credit cards (Visa, MasterCard, American Express)
Bank transfer (T/T)
Cryptocurrencies (USDT, Bitcoin, Ethereum)
All Ubenimex transactions are encrypted to ensure security and confidentiality.
Disclaimer
Ubenimex is supplied strictly for laboratory research purposes. Not for human or veterinary use. Researchers must follow institutional safety and chemical handling protocols. Supplier assumes no liability for misuse.
References
Additional information
| Weight | 1.1 kg |
|---|---|
| Dimensions | 18 × 16 × 18 cm |
What is Ubenimex used for in preclinical research?
Ubenimex is an aminopeptidase inhibitor used to study immune modulation, apoptosis, tumor cytotoxicity, and cancer microenvironment regulation in preclinical models.
Which enzymes does Ubenimex inhibit?
It selectively inhibits aminopeptidases such as CD13 (aminopeptidase N) and LTA4H, affecting tumor proliferation and immune responses.
What is the purity of Ubenimex lyophilized powder?
All batches are verified at ≥99% purity using HPLC, MS, and NMR.
How should Ubenimex powder be stored?
Store at 2–8 °C, protect from light and moisture. Avoid repeated freeze-thaw cycles.
Which solvents are compatible with Ubenimex?
It is soluble in water, DMSO, ethanol, and laboratory-grade buffers.
Can Ubenimex be used in combination therapy studies?
Yes, it is commonly combined with chemotherapeutics, immunomodulators, or kinase inhibitors to evaluate synergistic or antagonistic effects.
How does Ubenimex enhance immune responses?
By inhibiting CD13 and LTA4H, it enhances T-cell and NK-cell activity and modulates cytokine production.
How does Ubenimex induce apoptosis?
Through mitochondrial depolarization, ROS generation, caspase-3/-9 activation, and G1/S cell-cycle arrest.
Can Ubenimex powder be used for in vivo studies?
Yes, the lyophilized form allows precise reconstitution for dosing in animal models.
Is special laboratory handling required?
Yes, use PPE and a fume hood; strictly for research use due to cytotoxic properties.
Is bulk ordering of Ubenimex available?
Yes, OEM and bulk production are available from verified chemical manufacturers.
Which analytical methods confirm batch quality?
HPLC, MS, and NMR are used, with each batch supplied with a Certificate of Analysis (CoA).
Does Ubenimex affect cell-cycle checkpoints?
Yes, it induces G1/S phase arrest and modulates apoptosis in tumor cells.
Can Ubenimex be used to study resistance mechanisms?
Yes, it is applied to explore tumor and immune cell resistance via aminopeptidase expression or alternative signaling pathways.
Are high-purity Ubenimex powders available for research?
Yes, all batches meet ≥99% purity standards.
What preclinical applications are suitable for Ubenimex?
Immune modulation, apoptosis studies, tumor cytotoxicity, microenvironment research, and combination therapy evaluation.
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