Fosaprepitant Dimeglumine 0.15?g
$1.00
Fosaprepitant Dimeglumine Injection (brand: Mengsha®) is a neurokinin?1 (NK?) receptor antagonist developed by Shandong Luoxin Pharmaceutical Co., Ltd. (NMPA No.?H20223351; Code?86904141003343). Supplied as 0.15?g per vial of lyophilized powder (1 vial/box). This intravenous prodrug converts to aprepitant, widely used in research to prevent acute and delayed chemotherapy-induced nausea and vomiting (CINV). Strictly for laboratory research?Please consult the staff for other purposes?
描述
Fosaprepitant Dimeglumine Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Fosaprepitant Dimeglumine Injection (Mengsha®) |
| Strength | 0.15?g fosaprepitant per vial |
| Quantity | 1 vial per box |
| Dosage Form | Lyophilized powder for injection |
| Approval Number | China NMPA H20223351 |
| Product Code | 86904141003343 |
| Manufacturer | Shandong Luoxin Pharmaceutical Co., Ltd. |
| CAS Number | 172673?20?0 (fosaprepitant) en.wikipedia.orgzh.wikipedia.org+1en.wikipedia.org+1 |
| Molecular Formula | C??H??F?N?O?P?·?dimeglumine |
| Mechanism of Action | Intravenous prodrug of aprepitant ? NK? receptor antagonist |
| Intended Use | Laboratory research only — Not for clinical or veterinary use |
Fosaprepitant Dimeglumine Mechanism of Action
Fosaprepitant is a phosphorylated prodrug converted in vivo into aprepitant, a potent NK? receptor antagonist. It inhibits substance P binding in the brain’s vomiting center, thus preventing both acute and delayed CINV.
Research & Pharmacology Context
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Intravenous fosaprepitant is bioequivalent to oral aprepitant, offering research flexibility when oral dosing is unsuitable
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Studies show its effectiveness in combination with 5-HT? antagonists and corticosteroids to prevent both acute and delayed emesis in high-emetogenic chemotherapy (HEC)
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Conversion to aprepitant occurs rapidly—levels rising within 30 minutes post-infusion.
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Dimeglumine form included in China’s 2019 National Encouraged Generic Drug List .
Research Applications
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CINV prevention studies in preclinical chemotherapy models
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NK? receptor antagonism research: comparing IV vs oral administrations
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Combination protocols with 5-HT? antagonists and steroids
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Dose-timing studies of acute/delayed emesis models
?? Research?Use Only Disclaimer
This product is supplied strictly for laboratory research and development use. Not intended for clinical, diagnostic, therapeutic, or veterinary applications.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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