Description

Product Description

Group A Streptococcus (GAS) Injection is a laboratory research tool derived from Streptococcus pyogenes, a gram-positive, β-hemolytic bacterium known for its role in human disease and immune modulation. This bacterial preparation is designed to support high-quality research into host-pathogen interactions, innate and adaptive immune responses, and the development of novel immunotherapies and vaccines.

The product is supplied as a sterile, lyophilized preparation that can be reconstituted for in vitro cell culture experiments or in vivo animal models. GAS produces a variety of virulence factors, including M proteins, streptolysins, and exotoxins, which allow researchers to investigate mechanisms of pathogenicity and immune evasion.

Research studies using GAS Injection have demonstrated its ability to modulate cytokine production, activate dendritic cells, and stimulate T and B lymphocyte responses. These features make it a valuable model for studying bacterial infection mechanisms and for screening potential antimicrobial agents or immunomodulatory compounds.

This preparation supports reproducible research by providing standardized bacterial material with controlled concentration, ensuring that experimental variability is minimized. The sterile, high-purity formulation is compatible with diverse experimental designs, including immunocytochemistry, flow cytometry, gene expression profiling, and animal infection models.

GAS Injection has been extensively employed in preclinical research to study:

• Pathogen-induced inflammation and immune activation;

• Mechanisms of bacterial adhesion, invasion, and toxin production;

• Vaccine efficacy and adjuvant testing;

• Host susceptibility and genetic factors influencing infection outcomes.

Its laboratory-grade standard ensures that researchers can perform experiments with reliable and consistent material, enabling accurate interpretation of immune responses and antibacterial effects.

Product Specifications

Mechanism of Action

Group A Streptococcus Injection functions as a model pathogen to study immune activation, host-pathogen interactions, and antibacterial effects in preclinical research. Its mechanisms of action can be summarized as follows:

1. Host Immune Activation

GAS expresses multiple pathogen-associated molecular patterns (PAMPs) recognized by Toll-like receptors (TLRs) on immune cells. Binding to TLR2 and TLR4 activates downstream NF-κB signaling pathways, resulting in cytokine and chemokine production. This facilitates the recruitment of neutrophils, macrophages, and dendritic cells to the site of infection in experimental models.

2. Modulation of Adaptive Immunity

Group A Streptococcus The M protein and other surface antigens stimulate antigen-presenting cells, leading to T-cell activation and B-cell differentiation. GAS Injection research enables the study of antibody-mediated neutralization, T-helper cell polarization, and long-term memory response development.

3. Cytotoxic and Virulence Factors

Streptolysins (O and S) and other exotoxins produced by GAS can lyse host cells in vitro, allowing researchers to analyze host cell susceptibility, bacterial cytotoxicity, and tissue damage mechanisms. These factors are instrumental in evaluating therapeutic or vaccine efficacy against GAS-induced damage.

4. Inflammatory Response Modulation

GAS Injection induces pro-inflammatory mediators, including IL-1β, IL-6, TNF-α, and interferons. Controlled exposure in cell cultures or animal models helps researchers investigate inflammatory signaling, cytokine storms, and therapeutic modulation strategies.

5. Pathogen-Host Interaction Studies

Group A Streptococcus GAS interacts with extracellular matrix proteins (fibronectin, fibrinogen) via adhesins, allowing studies on bacterial adhesion, invasion, and immune evasion. Researchers can evaluate intervention strategies such as small-molecule inhibitors, monoclonal antibodies, or immunomodulatory peptides.

Side Effects

In laboratory models, GAS Injection is strictly intended for controlled research use. Handling must follow biosafety level 2 (BSL-2) guidelines. Potential risks include:

• Cytotoxic effects in vitro at high concentrations;

• Immune overactivation leading to systemic inflammation in animal models;

• Cross-contamination if aseptic techniques are not observed.

Proper protective equipment (PPE), sterile handling, and adherence to institutional biosafety protocols are mandatory. GAS Injection is not for human or veterinary therapeutic use.

Keywords

Group A Streptococcus Injection, Streptococcus pyogenes research, immunomodulatory agent, bacterial virulence, host-pathogen studies, vaccine research, antibacterial assays, factory biological reagent supplier, high-purity bacterial preparation

Shipping Guarantee

All Group A Streptococcus shipments are handled using validated cold-chain logistics to preserve bacterial integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Group A Streptococcus ensure product authenticity, verified laboratory-grade purity, and compliance with analytical standards. Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Group A Streptococcus provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Group A Streptococcus products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.