Description

Product Description

Granisetron Hydrochloride is a synthetic, highly potent 5-HT3 receptor antagonist designed for laboratory research purposes. It binds selectively to 5-HT3 receptors, inhibiting ion channel opening and subsequent neuronal depolarization. This blockade allows researchers to explore serotonergic signaling pathways, study receptor-mediated excitatory currents, and evaluate pharmacodynamic interactions with other neurotransmitter systems.

In preclinical models, Granisetron Hydrochloride has been used to investigate mechanisms of nausea and vomiting, receptor desensitization, and the modulation of gastrointestinal motility. It is particularly valuable in assays examining serotonin-induced electrophysiological responses, receptor-ligand binding kinetics, and downstream intracellular signaling events.

The compound demonstrates high solubility in polar solvents, allowing for precise dosing in in vitro cellular assays. Its hydrochloride salt form ensures chemical stability and reproducibility across experiments. Granisetron Hydrochloride is frequently employed as a reference standard in receptor binding studies, high-throughput screening for novel serotonergic modulators, and electrophysiological assays involving patch-clamp or microelectrode recordings.

Furthermore, Granisetron Hydrochloride is utilized in CNS-focused research, including studies of neuronal excitability, synaptic plasticity, and interactions with other neurotransmitter receptor systems. It also serves as a tool to investigate gastrointestinal 5-HT3 receptor functions in organoid models and ex vivo tissue assays. Its broad utility makes it indispensable for pharmacological profiling, mechanism-of-action studies, and preclinical research in neuroscience and gastrointestinal physiology.

Product Specifications

Mechanism of Action

Granisetron Hydrochloride exerts its pharmacological effects by selectively antagonizing 5-HT3 receptors. These receptors are ligand-gated ion channels present in central and peripheral neurons, as well as gastrointestinal tissues. Granisetron Hydrochloride blocks serotonin binding, inhibiting ion flux and preventing depolarization, which is critical for mediating nausea and emesis pathways.

1. Selective Receptor Blockade
   Granisetron binds specifically to 5-HT3 receptors, preventing receptor activation and downstream excitatory signaling.

2. Neuronal Electrophysiology Studies
   In vitro electrophysiological assays demonstrate that Granisetron Hydrochloride reduces action potential firing in serotonin-sensitive neurons, providing insight into receptor function and modulation.

3. Gastrointestinal Motility Regulation
   Preclinical assays show that Granisetron modulates smooth muscle contractility by inhibiting enteric 5-HT3 receptor signaling, making it valuable for gut physiology research.

4. Receptor Desensitization Research
   Granisetron is used to study receptor desensitization kinetics, internalization, and downstream intracellular signaling pathways in both CNS and peripheral neurons.

5. Combination Pharmacology
   It can be employed in combination studies to examine interactions with other serotonergic, dopaminergic, or cholinergic modulators in complex signaling networks.

   

Side Effects (Research Context)

In controlled laboratory experiments, Granisetron Hydrochloride is generally non-toxic at standard experimental concentrations. Researchers should assess cytotoxicity in cell cultures and tissue preparations as a precaution. Standard laboratory safety measures, including PPE, fume hoods, and biosafety protocols, should be followed. Granisetron Hydrochloride is not intended for human or veterinary use.

Keywords

Granisetron Hydrochloride, 5-HT3 receptor antagonist, MDL 73539, Kytril HCl, antiemetic research, neuropharmacology, gastrointestinal studies, receptor binding, peptide wholesale China, factory peptide supplier, research chemical, high purity compound, OEM research chemical production

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve compound integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

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Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.