描述
Product Specifications
Attribute | Details |
---|---|
Product Name | Dexmedetomidine Hydrochloride Injection |
Generic Name | Dexmedetomidine hydrochloride |
CAS Number | 113775?47?6 ringpu.com+7en.wikipedia.org+7go.drugbank.com+7 |
Molecular Formula | C??H??N?·HCl |
Molecular Weight | ~236.7?g/mol |
Dosage Form | Lyophilized powder for injection |
Strength | 0.2?mg per 2?mL vial |
Pack Size | 5 vials per box |
Approval Number | H20203335 (NMPA) |
Product Code | 86902581000113 |
Manufacturer | Sinopharm Group Langfang Co., Ltd. |
Storage | Store at 2–8?°C, protect from light |
Intended Use | Laboratory research only |
Mechanism of Action
Dexmedetomidine is a highly selective ???adrenergic agonist (??:?? ?1620:1), producing sedation by decreasing noradrenergic activity in the locus ceruleus and providing analgesia via spinal pathways—without significant respiratory depression.
Research Applications & Pharmacology
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Sedation & analgesia models: Commonly applied in rodent, canine, and feline models to induce calmness and reduce anxiety or pain pre-procedure .
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Dosage examples: IM 125–500?µg/m² or IV 375?µg/m² in dogs; IM 40?µg/kg in cats .
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Pharmacokinetics: High protein binding (~94%), 2–4?hr half-life; hepatic metabolism; excretion via urine.
Safety Profile & Handling
Observed effects:
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Sedation, mild bradycardia or hypotension, transient respiratory depression in high doses .
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Avoid mixing with other sedatives to reduce overdose risks.
Handling precautions:
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Reconstitute per instructions (e.g., to 4?µg/mL for IV infusion) .
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Use aseptic technique, monitor vitals, and properly dispose of vials as pharmaceutical waste.
?? Research?Use Disclaimer
This product is intended solely for laboratory research. It is not approved for clinical, diagnostic, therapeutic, or veterinary use. Improper usage may compromise subject safety and data validity.
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