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Levobupivacaine Hydrochloride 37.5?mg ×?5 Vials Wholesale price comparison
$1.00
Levobupivacaine is the S?enantiomer of bupivacaine, a long?acting amide?type local anesthetic offering reduced cardiotoxicity and prolonged nerve blockade. Each 5?mL vial contains 37.5?mg. Produced by Yichang Renfu Pharmaceutical Co., Ltd., approved under NMPA H20193347, product code 86902000002308, barcode 6930829980983.
?? For laboratory research use only.?Please consult the staff for other purposes?
Description
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Levobupivacaine Hydrochloride Injection (Burolog®) |
| Generic Name | Levobupivacaine Hydrochloride (S?(-)-bupivacaine) |
| CAS Number | 27262?48?2 zh.wikipedia.org+15pubchem.ncbi.nlm.nih.gov+15m.gelonghui.com+15go.drugbank.com+2en.wikipedia.org+2finance.sina.com.cn+2 |
| Molecular Formula | C??H??N?O·HCl |
| Molecular Weight | ~324.9?g/mol |
| Dosage Form | Sterile solution for injection (IV/IM/epidural) |
| Strength | 37.5?mg per 5?mL vial |
| Pack Size | 5 vials per box |
| Approval Number | H20193347 (China NMPA) |
| Product Code | 86902000002308 |
| Manufacturer | Yichang Renfu Pharmaceutical Co., Ltd. |
| Barcode | 6930829980983 |
| Storage | Store at 2–8?°C, protected from light |
| Intended Use | Laboratory research use only |
Mechanism of Action
Levobupivacaine blocks voltage-gated sodium channels in peripheral nerves, preventing depolarization. Compared to racemic bupivacaine, it offers reduced cardiotoxicity and neurotoxicity while providing a long-acting nerve block—up to 16 hours medicines.org.uk+14en.wikipedia.org+14journals.lww.com+14.
Research Applications & Pharmacology
Regional anesthesia: Ideal for epidural, spinal, peripheral nerve, infiltration, and ophthalmic blocks .
Analgesia models: Used in postoperative and labor pain research. Dosing ranges typically from 1.25–7.5?mg/mL, depending on application .
Pharmacokinetics: Onset within 15?min, half-life ~80?min, duration up to 16?hrs, ~97% protein bound, metabolized hepatically, excreted renally (71%) and fecally (24%) .
Safety Profile & Handling
Toxicity & side effects:
Compared to bupivacaine, it has a better safety profile, with less cardiovascular and CNS risk .
Potential side effects include CNS symptoms (e.g., dizziness, seizures) and cardiac effects in overdose .
Research handling tips:
Use PPE, aseptic technique, and dose according to animal model size.
Monitor cardiovascular and neurological functions; prepare to manage airway/ventilation.
Dispose of unused vials as hazardous pharmaceutical waste.
?? Research?Use Disclaimer
This product is intended exclusively for laboratory research. It is not approved for therapeutic, clinical, diagnostic, or veterinary uses. Misuse may cause safety hazards and compromise research validity.
Additional information
| Weight | 1.1 kg |
|---|---|
| Dimensions | 18 × 16 × 18 cm |
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