Description

Rotundine Sulfate Injection Product Specifications

Rotundine Sulfate Injection Mechanism of Action

Rotundine (L-tetrahydropalmatine) is an isoquinoline alkaloid with analgesic, sedative, and muscle-relaxant properties. It exhibits its effects by antagonizing central dopamine receptors (D1, D2) and modulating serotonin/adrenergic pathways . Notably, its analgesic and sedative mechanisms are non-opioid and independent of GABAergic or prostaglandin systems.

Research Applications & Pharmacology

• Analgesic and pain modulation: Effective against inflammatory and neuropathic pain models mdpi.com+15pmc.ncbi.nlm.nih.gov+15chemicalbook.com+15.

• CNS sedation & anxiety studies: Used to explore sedative and anxiolytic effects, with measurable central nervous system activity .

• Substance use disorder models: Demonstrated efficacy in reducing cravings and withdrawal in opioid and stimulant dependence .

• Neuroprotective & cardiovascular research: Protective effects against ischemia-reperfusion injuries .

• Formulation and PK/PD studies: Insights into injectable stability and pharmacokinetic interactions.

Safety Profile & Handling

• Toxicity: Low adverse effects in preclinical doses; overdose may cause sedation, bradycardia, or rare liver effects.

• Precautions: Use PPE (gloves, lab coat, mask), avoid skin or eye contact, and ensure sterile handling.

• Storage: Keep sealed, in cool dry conditions, away from light.

• Disposal: Dispose of residues and vials under biohazard or pharmaceutical waste protocols.

Core Keywords

rotundine sulfate injection, L-tetrahydropalmatine injection, rotundine CAS 10097-84-4, analgesic research, sedative alkaloid, CNS pharmacology, lab injection vials, wholesale rotundine

Research?Use Disclaimer

This product is intended exclusively for laboratory research and is not approved for clinical, therapeutic, diagnostic, or veterinary use. Improper handling may pose health risks—always follow institutional and safety protocols.