Description
Product Specifications
| Specification | Details |
|---|---|
| Product Name | Macrogol?4000 Powder (ChangWeiKang) |
| Generic Name | Polyethylene Glycol?4000 (PEG?4000) |
| CAS Number | 25322?68?3 en.wikipedia.org+13researchgate.net+13 |
| Molecular Formula | H–(OCH?CH?)?–OH, average MW ??4000?Da |
| Molecular Weight | 3500–4500?g/mol (average ~4000?Da) |
| Formulation | Water-soluble powder |
| Strength | 10?g per sachet |
| Pack Size | 10 sachets per box |
| Approval Number | H20061086 (NMPA, China) |
| Product Code | 86901027000106 |
| Manufacturer | Chongqing SinoBio Pharmaceutical Co., Ltd. |
| Barcode | 6903283400830 |
| Storage Conditions | Store at 15–30?°C, in a dry, ventilated place away from light |
| Intended Use | For laboratory research only |
Mechanism of Action
Macrogol?4000 is a non-absorbable, inert osmotic laxative that retains water in the colon by hydrogen bonding, softening stool and improving GI motility. It’s well-tolerated and effective for constipation and bowel preparation models.
Research Applications & Pharmacology
Chronic constipation models: First-line osmotic laxative in preclinical motility studies
Bowel preparation: Used in animal models for colon cleansing before endoscopy
Formulation science: Excipient studies on solubility, viscosity, and stability
Hydration/electrolyte balance: Ideal for osmotic research owing to negligible absorption
Comparative studies: Demonstrated higher efficacy and tolerability vs. lactulose, with less gas/flatulence
Safety Profile & Handling
Safety: High molecular weight PEG is biologically inert and well tolerated; minimal systemic absorption (<4%)
Possible effects: May cause mild bloating, abdominal pain, diarrhea
Laboratory precautions: Use standard PPE; avoid inhalation of powder; weigh and dissolve with lab-grade water
Storage: Keep in a dry area at room temperature, protected from moisture
Disposal: Dispose of unused powder and solutions per chemical waste protocols
Core Keywords
macrogol 4000 powder, PEG 4000 research, osmotic laxative powder, CAS?25322?68?3, chronic constipation model, bowel prep research, ChangWeiKang macrogol, wholesale PEG 4000
Research?Use Disclaimer
This product is intended only for laboratory research purposes. It is not approved for clinical, therapeutic, diagnostic, or veterinary use. Improper use may pose health risks. Please follow institutional safety protocols.


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