Agomelatine Tablets 25?mg (Pusike ) Low price wholesale

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Agomelatine (brand name: Pusike ) is a melatonergic antidepressant agent presented as 25?mg oral tablets. Manufactured by Shandong Jingwei Pharmaceutical Co., Ltd., this compound is used for laboratory research into circadian rhythm, depression, and melatonin receptor studies. Each box contains 14 tablets.?? Strictly intended for scientific research use only.?Please consult staff for other specifications and uses?

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描述

Agomelatine is a novel antidepressant with a dual mechanism of action as a melatonin receptor agonist (MT?/MT?) and serotonin 5-HT?C receptor antagonist. It is widely studied in research involving mood regulation, neurogenesis, sleep-wake cycles, and chronobiology.

Contents hide

1 Product Specifications

2 Mechanism of Action

3 Research Applications

4 Safety & Handling

5 Research Use Disclaimer

Product Specifications

Parameter	Details
Product Name	Agomelatine Tablets
Brand Name	Pusike
Active Ingredient	Agomelatine
CAS Number	138112-76-2
Molecular Formula	C15H17NO2
Molecular Weight	243.3 g/mol
Strength	25?mg per tablet
Formulation	Oral tablets
Pack Size	14 tablets per box
Approval Number	H20249128 (NMPA, China)
Drug Code	86904111000617
Manufacturer	Shandong Jingwei Pharmaceutical Co., Ltd.
Storage Conditions	Store in a cool, dry place (15–25°C); protect from light
Research Use	Laboratory research only

Mechanism of Action

Agomelatine exhibits a dual mechanism:

Agonist at MT? and MT? receptors, promoting circadian rhythm normalization.
Antagonist at 5-HT?C receptors, resulting in increased dopamine and norepinephrine release in the frontal cortex.

This unique action is useful in research models of depression, sleep disturbance, and neurochemical imbalance.

Research Applications

Depression & Mood Disorders
Used in preclinical models simulating major depressive disorder (MDD) and seasonal affective disorder (SAD).
Sleep-Wake Cycle Studies
Improves sleep onset and continuity in animal circadian disruption models.
Neuroplasticity & BDNF
Shown to upregulate BDNF expression, supporting studies on neuroregeneration.
Non-serotonergic Antidepressant Research
Useful for investigating alternative antidepressant pathways without SSRI-like adverse effects.

Safety & Handling

Handling: Use gloves and protective equipment. Avoid direct contact with tablet powder.
Storage: Keep sealed at room temperature. Protect from humidity.
Stability: Shelf-stable for up to 36 months under recommended conditions.
Toxicology: At high doses in lab settings, may cause hepatotoxic effects—handle with caution in long-term studies.

Research Use Disclaimer

This product is intended exclusively for laboratory research purposes. It is not approved for human, clinical, or veterinary application. Users must follow institutional guidelines and local laws. Improper use may result in serious health risks.

其他信息

重量	1.2 公斤
尺寸	42 × 36 × 42 厘米

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Q1: What is the CAS number of Agomelatine?

A1: The CAS number is 138112-76-2, used for accurate compound tracking and database referencing.

Q2: Is this product for clinical treatment?

A2: No. This version is strictly for laboratory and experimental use, not for human administration.

Q3: How does Agomelatine differ from SSRIs?

A3: Unlike SSRIs, Agomelatine does not inhibit serotonin reuptake but modulates circadian rhythm and enhances dopamine/noradrenaline indirectly.

Q4: Can I purchase this in bulk for institutional research?

A4: Yes. We offer bulk and OEM supply options. Contact us directly for volume pricing and logistics.

Q5: Do you offer COA and SDS documents?

A5: Yes, Certificates of Analysis and Safety Data Sheets are available upon request.