Description

Tiopronin is a thiol-containing compound (N-(2-mercaptopropionyl)glycine) that reduces cystine to soluble complexes, chelates heavy metals, and scavenges free radicals. This injectable form is suitable for research involving hepatoprotection, detoxification, antioxidant activity, and metabolic diseases.

Product Specifications

Mechanism of Action

Tiopronin’s free thiol group breaks disulfide bonds in cystine, forming soluble mixed disulfides to prevent stone formation. It also chelates heavy metals and acts as an antioxidant by neutralizing reactive oxygen species .

Research Application Areas

• Cystine Kidney Stone Prevention: Using animal models to evaluate efficacy Heavy Metal Detoxification: Chelation in toxic exposure studies

• Hepatoprotection & Liver Injury Models: Due to antioxidant & detox effects

• Oxidative Stress & Antioxidant Assays: Radical scavenging in cell and tissue models

Safety & Handling

• Research Dosing: Typically 0.1–0.2?g IV daily in rodent models, but protocols vary.

• Side Effects: Generally mild (e.g., nausea, headache); rare nephrotoxicity reports exist.

• Contraindications: Thiol hypersensitivity.

• Storage: Refrigerate at 2–8?°C; avoid light and freezing.

• Handling: Use aseptic technique, gloves, goggles; follow lab biosafety protocols.

Core Keywords

tiopronin injection, tiopronin sodium, CAS 1953?02?2, H20198007, thiol antioxidant injection, cystine stone prevention agent, hepatoprotection thiol, lab-grade tiopronin, wholesale tiopronin vials

Research Use Disclaimer

Intended strictly for laboratory and preclinical research. Not approved for clinical, therapeutic, diagnostic, or veterinary use. Misuse may pose health or legal risks. Use under approved institutional protocols only.