Description

Indomethacin is a potent NSAID from the indole-acetic acid family that non-selectively inhibits COX-1 and COX-2 enzymes, reducing prostaglandin-mediated inflammation, pain, swelling, and stiffness?. Topical delivery via gel patch targets local musculoskeletal and joint areas while minimizing systemic exposure?.

This YilaiBang/Duyipian patch (14×10?cm, 3 pieces per bag) is used in research models of osteoarthritis, rheumatoid arthritis, cervical spondylosis, and sprain. It is manufactured by Hubei Bingbing Pharmaceutical Group Co., Ltd., approved under China NMPA registration H20113287, with drug code 86906791000017 and barcode 6949275700625.

?? Strictly for laboratory research use only. Not approved for clinical or veterinary application.

Indomethacin Gel Patch Product Specifications

Indomethacin Gel Patch Mechanism & Research Applications

Indomethacin inhibits COX-1 and -2, significantly reducing prostaglandin synthesis—effective for relief of inflammation, pain, and swelling?. Extensively used in:

• Osteoarthritis and rheumatoid arthritis research models

• Cervical spondylosis simulations

• Sprain/strain and localized inflammation models

• Comparative topical NSAID pharmacodynamics studies

• Percutaneous absorption and release profiling with hydrogel-based patches?

Side Effects (Research Observations)

Topical or local administration of indomethacin may cause:

• Mild skin irritation or localized hypersensitivity

• Potential for dermal redness or contact dermatitis

• Rare systemic effects via absorption—gastrointestinal, renal, or cardiovascular—mirroring oral NSAIDs?

Implement monitoring in in vivo models and ensure ethical route-specific testing protocols.

Safety & Handling

• Research Use Only: Not for humans or animals

• PPE Required: Gloves and protective clothing when handling

• Application: Apply to clean, intact skin; follow institutional protocols

• Storage: Keep sealed, room temperature, away from direct heat

• Disposal: Dispose used patches per chemical/pharmaceutical waste guidelines

Core Keywords

Indomethacin gel patch, topical NSAID research, YilaiBang patch, Duyipian indomethacin, 14x10cm gel plaster, osteoarthritis model patch, lab-use indomethacin, NMPA H20113287 topical, Hubei Bingbing indomethacin patch

Research Use Disclaimer

This product is strictly for laboratory research use and not approved for any diagnostic, therapeutic, clinical, or veterinary applications. Misuse may lead to safety or legal consequences. Always adhere to institutional biosafety and drug-handling protocols.