Description

Ezetimibe is a potent cholesterol absorption inhibitor that selectively blocks the Niemann-Pick C1-Like 1 (NPC1L1) protein on the intestinal brush border. This action reduces the absorption of dietary and biliary cholesterol, making it a key compound in the study of cholesterol metabolism and cardiovascular disease research.

Nobetan formulation offers a standardized 10mg dose per tablet, with 24 tablets per box, produced by Zhejiang Nuode Pharmaceutical Co., Ltd. This product is NMPA-approved (H20243253) and intended solely for laboratory use, including in vitro and in vivo cholesterol metabolism assays, pharmacokinetic studies, and drug interaction research.

?? For laboratory research only. Not for human or veterinary use.

Product Specifications

Mechanism & Research Applications

Ezetimibe selectively inhibits the Niemann-Pick C1-Like 1 (NPC1L1) protein located on the intestinal brush border. This inhibition reduces the absorption of dietary and biliary cholesterol, making it an effective tool for studying cholesterol metabolism.

The compound is widely used in research focused on lipid homeostasis, cardiovascular disease mechanisms, and cholesterol-lowering strategies. It supports both in vitro and in vivo pharmacokinetic studies, enabling researchers to evaluate the efficacy and interactions of cholesterol absorption inhibitors.

Additionally, Ezetimibe tablets are utilized in drug interaction assays and in the development of novel therapeutics targeting cholesterol regulation pathways.

Side Effects (Observed in Research Models)

• Potential mild gastrointestinal effects in animal models

• Minimal influence on hepatic enzyme activity in standard doses

• Rare allergic reactions in sensitized test subjects

• Adverse effects should be monitored according to experimental protocols

Safety & Handling

• Use Restriction: For laboratory research only; not for clinical or veterinary use

• Protective Equipment: Gloves, lab coat, and safety goggles recommended during handling

• Storage: Keep sealed, store below 25°C, protect from moisture and light

• Disposal: Follow institutional and environmental guidelines for chemical waste

Research Use Disclaimer

This product is intended exclusively for laboratory research use. It is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Improper use may present health or legal risks. Always comply with local biosafety and research ethics protocols.