描述
Sacubitril/Valsartan Sodium Tablets (brand: Zuobei) combine two active components—sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker (ARB). This dual-action compound is used in laboratory studies focused on cardiovascular diseases, especially heart failure with reduced ejection fraction (HFrEF).
Each tablet delivers a total dose of 200mg, and this product is supplied as 7 tablets per box. It is manufactured by Zhejiang Anglikang Pharmaceutical Co., Ltd., with regulatory approval under China NMPA No. H20244371 and product code 86904606000498.
Note: This product is intended for laboratory research use only and not for human or veterinary use.
Sacubitril/Valsartan Sodium Product Specifications
Parameter | Details |
---|---|
Product Name | Sacubitril/Valsartan Sodium Tablets (Zuobei) |
Generic Name | Sacubitril and Valsartan Sodium |
CAS Number | 936623-90-4 (sacubitril) / 137862-53-4 (valsartan) |
Molecular Formula | C24H29NO5 (sacubitril) / C24H29N5O3 (valsartan) |
Molecular Weight | ~411.5 g/mol (sacubitril) / ~435.5 g/mol (valsartan) |
Dosage Form | Oral tablets |
Strength | 200mg (sacubitril/valsartan combined) |
Quantity | 7 tablets per box |
Approval Number | H20244371 (China NMPA) |
Product Code | 86904606000498 |
Manufacturer | Zhejiang Anglikang Pharmaceutical Co., Ltd. |
Intended Use | Laboratory research only |
Storage Conditions | Store in a cool, dry place below 25°C |
Sacubitril/Valsartan Sodium Mechanism & Research Applications
Sacubitril/Valsartan works through dual neurohormonal inhibition—blocking neprilysin to increase natriuretic peptides and inhibiting the RAAS system via angiotensin receptor blockade. This results in improved cardiac remodeling and reduced blood pressure in preclinical models.
Common research applications include:
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Animal models of heart failure with reduced ejection fraction (HFrEF)
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RAAS inhibition and cardiovascular modulation studies
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Neprilysin inhibition assays
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Pharmacodynamic interaction studies with other cardiovascular agents
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Investigating effects on cardiac fibrosis and remodeling
Safety & Handling
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Use Restriction: For laboratory research use only. Not for therapeutic, diagnostic, or veterinary use.
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Protective Equipment: Wear gloves, lab coat, and safety goggles.
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Storage: Store below 25°C in a dry environment, away from direct light.
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Disposal: Follow proper lab waste protocols and local regulations.
Research Use Disclaimer
This product is intended exclusively for laboratory research and is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Improper use may lead to health or legal risks. Users must comply with local safety and ethical research regulations.
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