Description

Epalrestat is an aldose reductase inhibitor (ARI) widely used in laboratory models investigating diabetic neuropathy, oxidative stress, and nerve conduction velocity. It plays a key role in research related to the polyol pathway, particularly under hyperglycemic conditions.

This formulation by Hebei Ruisen Pharmaceutical delivers 50mg per tablet and is ideal for in vitro and in vivo studies evaluating nerve protection and metabolic regulation in diabetic environments.

?? This product is for laboratory research use only. Not for human or veterinary consumption.

Product Specifications

Mechanism & Research Applications

Epalrestat inhibits aldose reductase, the key enzyme in the polyol pathway, which converts glucose to sorbitol. Under hyperglycemia, excess sorbitol contributes to nerve damage and oxidative stress. By blocking this conversion, epalrestat is valuable in exploring neuroprotective strategies for diabetic peripheral neuropathy (DPN).

It is commonly used in:

• Diabetic neuropathy simulation in rodent models

• Studies on nerve conduction velocity and oxidative stress

• Aldose reductase inhibition profiling

• Evaluation of glucose toxicity in endothelial cells

• Synergistic studies with insulin sensitizers

Observed Effects in Research Models

Research has shown that epalrestat:

• Improves nerve conduction velocity in diabetic rodents

• Reduces sorbitol accumulation in nerves and tissues

• Attenuates oxidative damage and improves antioxidant enzyme activity

• Enhances vascular function in high-glucose conditions

Safety & Handling

• Use Restriction: For research use only

• Protective Equipment: Gloves, goggles, and lab coat recommended

• Storage: Keep sealed and stored below 25°C, away from humidity

• Disposal: Dispose in accordance with chemical safety protocols

Research Use Disclaimer

This product is strictly intended for laboratory research use only. It is not for human consumption or therapeutic application. Misuse may result in legal and health consequences. Handle with standard lab safety precautions.