Description

Nitroglycerin (glyceryl trinitrate) is a potent nitrate vasodilator used in cardiovascular research for its effects on smooth muscle relaxation, coronary vasodilation, and hemodynamic modulation. It functions by converting to nitric oxide (NO), a powerful endogenous vasodilator.

This injectable formulation provides 5mg nitroglycerin per 1ml, with 10 ampoules per box, and is often utilized in laboratory settings to model angina, acute myocardial ischemia, and blood pressure regulation in pharmacodynamic and cardiovascular studies.

Manufactured by Shandong Shenglu Pharmaceutical Co., Ltd. under NMPA approval number H20058649. This product is not intended for human or veterinary use.

Product Specifications

Mechanism & Research Applications

Nitroglycerin is metabolized to nitric oxide (NO), which activates guanylate cyclase and increases cGMP, resulting in vascular smooth muscle relaxation. It primarily dilates veins and to a lesser extent, arteries, reducing preload and afterload, thereby lowering myocardial oxygen demand.

Research Applications:

• Coronary vasodilation studies

• Hemodynamic modulation

• Angina and ischemic heart disease modeling

• Smooth muscle relaxation mechanisms

• Nitric oxide signaling pathways

Known Side Effects in Research Use

• Hypotension (dose-dependent)

• Reflex tachycardia

• Headache due to vasodilation

• Dizziness or flushing

• Tolerance with repeated exposure

Safety & Handling Guidelines

• For laboratory use only

• Not for clinical, diagnostic, or therapeutic purposes

• Use gloves and protective eyewear during handling

• Avoid exposure to heat or flame (nitroglycerin is explosive in concentrated form)

• Dispose of according to institutional hazardous waste guidelines

Research Use Disclaimer

This product is provided exclusively for laboratory research and is not approved for use in humans or animals. Any unauthorized use may pose serious health or legal risks. Handle in accordance with laboratory safety protocols.