Description

Product Description

Elamipretide is a synthetic, short-sequence peptide extensively utilized in molecular and cellular research focusing on mitochondrial membrane dynamics, peptide–lipid interactions, and bioenergetic signaling pathways under controlled in vitro conditions. From a research perspective, Elamipretide serves as a model peptide for investigating how targeted amino acid sequences interact with specific phospholipid environments and influence molecular organization at the membrane level.

In laboratory settings, Elamipretide is commonly incorporated into experimental systems designed to explore mitochondrial-associated mechanisms without extending into organism-level interpretation. Its defined structure and reproducible synthesis make Elamipretide particularly suitable for comparative peptide studies, including analog evaluation, structure–function analysis, and mechanistic probing of peptide–membrane affinity.

As a research reagent, Elamipretide supports investigations into peptide-mediated modulation of membrane stability, redox-associated molecular events, and protein–lipid interface behavior. These studies are typically conducted using isolated mitochondrial fractions, artificial membrane systems, or cell-based platforms that allow precise environmental control. Such approaches enable researchers to focus on fundamental molecular interactions rather than downstream physiological interpretation.

The Elamipretide supplied by our facility is produced using standardized solid-phase peptide synthesis followed by multi-step purification. Each batch undergoes rigorous analytical verification to ensure sequence integrity, high chemical purity, and batch-to-batch consistency. This level of control is essential for reproducible experimental outcomes, particularly in comparative studies where subtle molecular differences can influence data interpretation.

Designed exclusively for research applications, Elamipretide is provided as a high-purity laboratory reagent suitable for mechanistic studies, assay development, and exploratory peptide research. Factory-direct manufacturing allows cost-effective bulk supply while maintaining stringent quality standards required by advanced research laboratories worldwide.

Product Specifications

Mechanism of Action

From a molecular research standpoint, Elamipretide is primarily studied as a membrane-interactive peptide with preferential affinity for specific phospholipid environments. Its sequence composition and charge distribution enable selective interaction with mitochondrial-associated lipid domains, making it a valuable tool for examining peptide–lipid organization and membrane-associated signaling processes in vitro.

Mechanistic investigations often focus on how Elamipretide associates with phospholipid head groups, influencing local membrane structure and microdomain stability. These interactions can be evaluated using biophysical assays, fluorescence-based membrane probes, and protein–lipid binding studies. By isolating these interactions under controlled laboratory conditions, researchers can assess how peptide structure contributes to membrane-associated molecular behavior.

Elamipretide is also employed in studies examining redox-related molecular processes at the membrane interface. In vitro experimental designs may evaluate how peptide–lipid interactions correlate with changes in electron transfer environments, protein conformation, or signaling molecule distribution. Importantly, such studies remain confined to molecular and cellular systems, emphasizing mechanistic interpretation rather than functional extrapolation.

Comparative analyses using Elamipretide and structurally related analogs further support structure–function mapping. Subtle sequence variations can be correlated with differences in membrane affinity or molecular stability, contributing to a deeper understanding of peptide design principles. These mechanistic insights are foundational for peptide chemistry, membrane biology, and bioenergetic research frameworks.System-level peptide analysis

Applications

Elamipretide is widely applied in in vitro research environments where controlled investigation of peptide–membrane interactions is required. Typical applications include mitochondrial membrane modeling, lipid–protein interaction assays, and mechanistic studies of peptide-mediated molecular organization.

In biochemical research, Elamipretide is utilized in artificial membrane systems such as liposomes or supported lipid bilayers to evaluate binding specificity and structural effects. These platforms allow precise manipulation of lipid composition, enabling researchers to dissect how Elamipretide responds to defined phospholipid environments.

Cell-based research models may also incorporate Elamipretide to explore intracellular membrane-associated molecular pathways. Such applications focus on signal modulation, oxidative balance at the molecular level, and peptide localization patterns within controlled experimental systems. Data generated from these studies support broader hypotheses related to peptide chemistry and membrane biology.

Additionally, Elamipretide is used in comparative peptide research, where it serves as a reference compound for evaluating novel analogs or modified sequences. Its well-characterized structure and reproducible performance make it a reliable benchmark in advanced laboratory studies.

Research Models

Elamipretide research is typically conducted using non-organismal experimental models designed to isolate molecular mechanisms. Commonly employed models include artificial lipid bilayers, mitochondrial membrane extracts, and cultured cell platforms optimized for biochemical analysis.

Lipid-based systems provide a simplified environment for studying peptide–membrane affinity and conformational effects. These models enable high-resolution analysis using spectroscopic, calorimetric, or imaging-based techniques. By controlling lipid composition and experimental parameters, researchers can directly correlate molecular structure with observed interaction patterns.

Cell-based research models further support investigation into intracellular peptide localization and membrane-associated signaling events. These systems allow integration of biochemical readouts with molecular imaging and proteomic profiling, facilitating multi-dimensional data interpretation while maintaining an in vitro research scope.

Together, these research models ensure that Elamipretide studies remain focused on fundamental molecular processes, providing reproducible and interpretable data suitable for advanced research programs.

Experimental Design Considerations

When designing experiments involving Elamipretide, researchers should prioritize standardization and comparability. Parallel testing conditions, consistent buffer systems, and appropriate controls are essential for reliable data interpretation. Concentration ranges should be selected based on assay sensitivity and detection limits rather than extrapolative assumptions.

Comparative studies benefit from inclusion of structurally related peptide analogs to support structure–function analysis. Documentation of peptide handling, reconstitution conditions, and storage history further enhances reproducibility across experimental runs.

Analytical endpoints should align with the intended mechanistic question, whether focusing on membrane binding affinity, molecular stability, or interaction-driven signaling patterns. Clear experimental objectives and transparent reporting practices are critical for generating interpretable results.

Laboratory Safety & Handling Guidelines

Elamipretide is supplied exclusively as a research-grade laboratory material. Standard laboratory safety practices should be followed when handling peptide reagents. Personnel should wear appropriate protective equipment, including gloves and lab coats, to minimize unintended exposure.

The lyophilized powder should be handled in a clean, controlled environment to prevent contamination. Reconstitution should be performed using suitable laboratory-grade solvents or buffers, and aliquoting is recommended to avoid repeated freeze–thaw cycles.

Storage under low-temperature, dry conditions helps preserve peptide integrity over extended periods. All handling procedures should align with institutional laboratory safety protocols and chemical hygiene guidelines.

Integration with Multi-Omic & Computational Studies

Elamipretide-based research increasingly integrates with multi-omic and computational approaches to enhance mechanistic interpretation. Proteomic and lipidomic analyses may be employed to assess molecular response patterns associated with peptide–membrane interaction studies.

Computational modeling supports visualization of peptide–lipid interfaces and prediction of conformational behavior under defined conditions. When combined with experimental data, these approaches provide a systems-level perspective on molecular interactions without extending beyond in vitro research boundaries.

Such integration strengthens hypothesis generation and supports data-driven refinement of experimental design in peptide research programs.

Keywords

 Elamipretide peptide, Elamipretide CAS 1177324-86-3, research-grade Elamipretide, high-purity Elamipretide, Elamipretide wholesale, Elamipretide factory supply, Elamipretide in vitro research

Shipping Guarantee

All Elamipretide shipments are securely packaged with appropriate environmental protection to maintain product integrity during transit. Batch identification and tracking documentation are provided to support laboratory record-keeping. Packaging protocols are designed to minimize contamination and degradation risks. Each shipment is inspected prior to dispatch. Global laboratory delivery is supported. Consistent logistics ensure research continuity.

Trade Assurance

Factory-direct manufacturing ensures consistent peptide quality, stable supply capacity, and competitive pricing. Each batch is accompanied by analytical documentation verifying purity and identity. Bulk and customized production options are available for research institutions. Quality management systems support long-term supply reliability. Direct sourcing reduces intermediary risk. Long-term research partnerships are supported.

Payment Support

We support Credit Card, Bank Transfer (TT), and Cryptocurrency payments including BTC, ETH, and USDT. All payment channels use encrypted transaction systems. International procurement requirements are fully supported. Flexible payment options facilitate global laboratory sourcing. Documentation can be provided for institutional accounting. Secure processing is guaranteed.

Disclaimer

This product is supplied strictly for laboratory research use. It is not intended for diagnostic, therapeutic, or other applied purposes. No claims are made regarding suitability beyond in vitro experimental systems. Use is restricted to qualified research personnel. All applications must comply with applicable laboratory regulations. The supplier assumes no responsibility for misuse outside defined research contexts.

References

• PubChem – Elamipretide (SS-31) Compound Summary
  National Center for Biotechnology Information (NCBI).
  Provides authoritative chemical identity, structure, molecular properties, and curated literature links relevant to Elamipretide research.
  https://pubchem.ncbi.nlm.nih.gov/compound/Elamipretide

• DrugBank Online – Elamipretide (DB11675)
  DrugBank Database, University of Alberta.
  Offers detailed molecular information, peptide characteristics, and mechanistic annotations suitable for research background reference.
  https://go.drugbank.com/drugs/DB11675

• NCBI – Peptide–Membrane Interaction and Mitochondrial Biology Resources
  National Center for Biotechnology Information.
  Comprehensive repository for peer-reviewed literature and mechanistic studies related to peptide–lipid interactions and mitochondrial-associated molecular processes.
  https://www.ncbi.nlm.nih.gov/

• Nature Reviews Molecular Cell Biology – Mitochondrial Membrane Organization and Dynamics
  Nature Publishing Group.
  Authoritative review articles discussing mitochondrial membrane structure, lipid–protein interactions, and experimental approaches relevant to Elamipretide research frameworks.
  https://www.nature.com/nrm/

• Journal of Biological Chemistry – Peptide–Lipid Interaction Mechanisms
  American Society for Biochemistry and Molecular Biology (ASBMB).
  Peer-reviewed studies addressing molecular mechanisms of peptide binding, membrane stabilization, and structure–function relationships.
  https://www.jbc.org/

• RCSB Protein Data Bank (PDB)
  Worldwide Protein Data Bank Consortium.
  Structural biology resource supporting computational modeling and visualization of peptide conformations and membrane-associated molecular interactions.
  https://www.rcsb.org/

• Frontiers in Molecular Biosciences – Peptide-Based Molecular Research
  Frontiers Media SA.
  Open-access reviews and research articles covering peptide chemistry, bioenergetics, and advanced experimental models applicable to Elamipretide studies.
  https://www.frontiersin.org/journals/molecular-biosciences