Description

Product Description

Sulanemadlin, also known as ALRN-6924, is a stabilized stapled peptide developed to inhibit the interaction between p53 and its negative regulators MDM2 and MDMX. Through this dual-target mechanism, the peptide supports restoration of p53 signaling activity, making it a valuable research tool in oncology and tumor biology investigations.

The molecule incorporates a hydrocarbon staple that stabilizes its α-helical conformation. This design significantly improves resistance to enzymatic degradation and enhances intracellular permeability compared with linear peptide analogs. As a result, the compound maintains structural integrity and biological consistency in complex experimental environments.

In cancer research, this peptide is frequently applied to study apoptosis induction, cell cycle regulation, and tumor suppressor pathway reactivation in p53-wild-type models. It also supports evaluation of resistance mechanisms observed with small-molecule MDM2 inhibitors and provides insight into alternative dual-inhibition strategies.

Beyond oncology, the compound serves as a representative model in stapled peptide engineering. Researchers use it to investigate peptide stabilization technology, intracellular delivery optimization, and structure–activity relationships. Its stabilized conformation enables systematic exploration of how peptide folding influences biological performance.

Supplied as a sterile lyophilized powder, Sulanemadlin allows long-term storage stability and flexible preparation for laboratory studies. Each production batch undergoes comprehensive analytical testing to ensure purity, identity, and reproducibility, supporting reliable application in advanced peptide biology and pharmaceutical research.

Product Specifications

Applications

Sulanemadlin is widely used in biomedical and pharmaceutical research focused on tumor suppressor regulation and peptide-based therapeutic development.

Typical applications include:

• p53 signaling pathway reactivation studies

• Dual MDM2 / MDMX inhibition research

• Cancer cell apoptosis mechanism investigations

• Tumor suppressor regulatory network analysis

• Stapled peptide stabilization studies

• Intracellular peptide delivery research

• Structure–activity relationship evaluation

• Oncology drug discovery screening models

In peptide chemistry research, this compound serves as a benchmark stapled peptide for evaluating conformational stabilization strategies. Its rigid α-helix enables researchers to analyze how peptide folding affects receptor binding and intracellular signaling efficiency.

In translational oncology models, Sulanemadlin supports investigation of resistance pathways associated with single-target inhibitors and contributes to next-generation peptide modulator development. It is also applied in combination studies to explore synergistic molecular interactions.

Overall, the peptide provides a reliable research platform for oncology signaling, peptide engineering, and molecular biology studies.

Packaging

The product is supplied in sterile sealed glass vials containing lyophilized powder. Bulk packaging, OEM labeling, and customized specifications are available for institutional and pharmaceutical research programs.

Storage & Transportation

Store at −20 °C in a dry and light-protected environment. Cold-chain transportation is recommended. Reconstituted solutions should be prepared under sterile conditions and used according to laboratory stability protocols.

Inquiry & Technical Consultation

For Certificates of Analysis, chromatographic data, or batch documentation related to Sulanemadlin, please submit your inquiry through the contact form. Technical support is available for qualified research partners.

Disclaimer

This product is intended for research use only.
Not for human or veterinary use.
All experimental procedures must comply with applicable laboratory and regulatory requirements.