Description

Endothelin 1 (Swine, Human) (TFA) is a biologically active 21-amino-acid peptide that acts as one of the most powerful endogenous vasoconstrictors. It plays a crucial role in vascular homeostasis, modulating vasoconstriction, cell proliferation, and hormone production. This peptide, produced to a purity of 99.95% and supplied with GMP standards, is valuable for research on cardiovascular diseases, pulmonary hypertension, and endothelial function. Its dual origin from swine and human sequences makes it applicable in cross-species studies.

Product Specifications

Mechanism of Action & Research Applications

Endothelin 1 binds to endothelin receptors ETA and ETB on vascular smooth muscle cells and endothelial cells, causing potent vasoconstriction and regulation of blood pressure. It also modulates cell proliferation, inflammation, and fibrosis. Researchers use this peptide to study cardiovascular diseases, pulmonary arterial hypertension, kidney diseases, and endothelial dysfunction. It serves as a tool to elucidate endothelin receptor signaling pathways and screen receptor antagonists.

Side Effects (For Research Context Only)

In experimental models, high doses of endothelin 1 may cause excessive vasoconstriction, increased blood pressure, and organ ischemia. Side effects observed are dose-dependent and context-specific.

Disclaimer

Endothelin 1 (Swine, Human) (TFA) is for laboratory research use only and not intended for human or veterinary diagnostic or therapeutic applications.