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Endothelin-1 (Swine, Human) (TFA) – Purity 99.95% | GMP Factory
Original price was: $35.00.$32.00Current price is: $32.00.
Endothelin-1 (Swine, Human) (TFA) is a high-purity synthetic vasoactive peptide identical in swine and human sequences. It is widely used in laboratory research involving endothelin receptor signaling, vascular tone regulation, and cardiovascular physiology studies.
Description
Product Description
Endothelin-1 is a 21-amino-acid peptide originally discovered in endothelial cells and recognized as one of the most powerful endogenous vasoconstrictors identified in mammalian systems. The amino acid sequence of Endothelin-1 is identical in swine and humans, allowing consistent application across comparative experimental models.
In biological systems, plays a central role in the regulation of vascular tone, smooth muscle contraction, and endothelial cell function. Its activity is mediated through interaction with endothelin receptor subtypes ETA and ETB, which are widely expressed in cardiovascular and renal tissues. Because of its strong receptor affinity and sustained signaling properties, is frequently used as a reference peptide in receptor activation and signal transduction assays.
This product is supplied as a trifluoroacetate (TFA) salt, a commonly adopted form that supports the stability and reproducibility of Endothelin-1 in controlled laboratory environments.
Product Specifications
| Item | Description |
|---|---|
| Product Name | Endothelin-1 (Swine, Human) (TFA) |
| Synonyms | ET-1; Endothelin-1 peptide; EDN1 |
| CAS Number | 117399-94-7 |
| Molecular Formula | C₁₀₃H₁₆₀N₃₄O₃₁S₄ |
| Molecular Weight | ~2492.9 g/mol |
| Amino Acid Sequence | Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp |
| Peptide Type | Linear peptide with two disulfide bridges |
| Form | Lyophilized powder |
| Purity | ≥98% (HPLC) |
| Strength Options | 0.1 mg / 0.5 mg / 1 mg |
| Appearance | White to off-white powder |
| Identity Verification | HPLC, Mass Spectrometry |
| Solubility | Soluble in water or dilute acidic aqueous solutions |
| Packaging | Sterile glass vial |
| Storage Condition | −20 °C, protected from light and moisture |
| Intended Use | For laboratory research use only |
Applications
Endothelin-1 is commonly utilized in laboratory research applications including:
Endothelin receptor activation and signaling studies
Vascular smooth muscle contraction assays
Cardiovascular and pulmonary circulation research
Endothelial function and dysfunction investigations
Evaluation of endothelin receptor antagonists
Storage & Stability
Lyophilized should be stored at −20 °C in a dry and light-protected environment. After reconstitution, Endothelin-1 solutions should be aliquoted to avoid repeated freeze–thaw cycles that may compromise peptide integrity.
Disclaimer
is intended for laboratory research use only and is not intended for diagnostic, therapeutic, or clinical applications.
Additional information
| Weight | 0.8 kg |
|---|---|
| Dimensions | 26 × 23 × 26 cm |
1. What is Endothelin-1 commonly used for in laboratory research?
Endothelin-1 is primarily used as a reference peptide in studies related to vascular tone regulation, endothelin receptor signaling, and cardiovascular physiology.
2. Are swine and human Endothelin-1 sequences the same?
Yes. The amino acid sequence of Endothelin-1 is identical in swine and humans, allowing cross-species experimental use.
3. What receptors does Endothelin-1 interact with?
Endothelin-1 interacts with endothelin receptor subtypes ETA and ETB, both of which are G protein-coupled receptors.
4. Why is Endothelin-1 supplied as a TFA salt?
The TFA salt form enhances peptide stability and supports consistent analytical characterization such as HPLC and mass spectrometry.
5. What concentration range is typically used in vitro?
Endothelin-1 is highly potent and is commonly applied at low nanomolar concentrations, depending on the experimental system.
6. How should Endothelin-1 be reconstituted?
Endothelin-1 may be reconstituted in sterile water or dilute acidic aqueous solutions. Aliquoting is recommended after reconstitution.
7. How should reconstituted Endothelin-1 be stored?
Reconstituted solutions should be stored at −20 °C and protected from light to maintain peptide stability.
8. Is Endothelin-1 suitable for antagonist screening assays?
Yes. Endothelin-1 is widely used as a standard agonist when evaluating endothelin receptor antagonists.
9. Does Endothelin-1 have long-lasting biological effects?
Yes. Endothelin-1 is known for strong receptor binding and relatively slow dissociation, which can result in sustained responses.
10. Is this product intended for clinical or therapeutic use?
No. Endothelin-1 is intended for laboratory research use only and is not approved for clinical or therapeutic applications.
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