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Trofinetide (CAS 853400-76-7) – Purity 99.90% | GMP Factory
$2.00
Trofinetide (NNZ-2566) is a synthetic analog of the neuropeptide GPE, demonstrating potent anti-inflammatory and neuroprotective properties. Manufactured under GMP with 99.90% purity—ideal for preclinical neuroscience, neurodevelopmental, and Rett syndrome research. Laboratory use only.?For wholesale prices, other specifications and uses, please consult our staff?
Description
Trofinetide is a stable analog of glycine-proline-glutamate (GPE), a naturally occurring IGF-1-derived neuropeptide. Engineered to improve pharmacokinetics, it offers enhanced anti-inflammatory, cytoprotective, and synaptic-supportive effects. It suppresses key inflammatory mediators (e.g., IL-1?, TNF-?, IFN-?), reduces neuroinflammation, and shows efficacy in Rett syndrome clinical models. As the first FDA-approved treatment for Rett syndrome, Trofinetide underscores its translational potential. For lab-scale studies, this product offers 99.90% purity and GMP-backed consistency.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Trofinetide (NNZ-2566) |
| Synonyms | NNZ-2566 |
| CAS Number | 853400-76-7 |
| Purity | ?99.90% (HPLC) |
| Classification | Synthetic GPE analog – neuroprotective peptide |
| Molecular Formula | C??H??N?O? |
| Molecular Weight | ~315.3 Da |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water and DMSO |
| Storage | –20 °C; protect from light and moisture |
| GMP Compliance | Yes |
| Intended Use | Laboratory research use only |
Mechanism of Action & Research Applications
Trofinetide reduces neuroinflammation by blocking pro-inflammatory cytokines and enhances synaptic function. It’s used extensively in:
Rett syndrome research and preclinical modeling
Neuroprotective studies targeting inflammation and apoptosis
Brain injury models—ameliorates synaptic loss and neuronal damage
Its mechanistic profile and clinical relevance make Trofinetide a powerful research tool for developmental neurobiology and neuroinflammation studies.
Side Effects (For Research Context Only)
Clinical data indicate manageable side effects, with the most frequent being:
Diarrhea and vomiting, often dose-related
Improved tolerability with gradual dosing
These considerations are important for designing translational and long-term studies.
Disclaimer
This product is strictly for laboratory research use only and not approved for human, veterinary, or therapeutic applications.
Additional information
| Weight | 0.8 kg |
|---|---|
| Dimensions | 29 × 22 × 29 cm |
What is Trofinetide?
Trofinetide is a synthetic analog of the GPE neuropeptide with neuroprotective and anti-inflammatory actions.
What is the CAS number of Trofinetide?
The CAS number is 853400-76-7.
How does Trofinetide work in neuroscience research?
It suppresses key inflammatory cytokines and supports synaptic health and function in disease models.
What are its primary research applications?
Used in Rett syndrome modeling, neuroinflammation, and brain injury studies.
Is this product made to GMP standards?
Yes—it is manufactured under GMP conditions.
What purity does this product offer?
This batch has a high purity of 99.90%.
What side effects have been observed?
Diarrhea and vomiting are most common; slow titration improves tolerability in clinical settings.
Can Trofinetide be used clinically?
No—it is labeled for research use only.
How should it be stored?
Store at –20 °C, protected from light and moisture.
Why is Trofinetide relevant in Rett syndrome research?
It is FDA-approved for RTT, demonstrating real-world efficacy and translational potential.
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