描述
Abaloparatide is a 34-amino acid synthetic peptide designed to selectively activate PTH1R, stimulating bone formation and increasing bone mineral density. It mimics the effects of endogenous parathyroid hormone-related protein but with distinct receptor binding dynamics that favor anabolic effects on bone. This makes it a valuable molecule in the study of osteoporosis and related metabolic bone diseases. Abaloparatide research helps explore novel treatments for bone loss, fracture prevention, and skeletal regeneration.
Product Specifications
Parameter | Details |
---|---|
Product Name | Abaloparatide |
Synonyms | BA058, Abaloparatide acetate (if applicable) |
CAS Number | 247062-33-5 |
Purity | 99.91% (HPLC) |
Molecular Formula | C176H286N52O52 |
Molecular Weight | Approx. 4115.87 Da |
Appearance | White to off-white lyophilized powder |
Solubility | Soluble in water and aqueous buffers |
Storage | –20°C, protect from light and moisture |
GMP Compliance | Yes |
Intended Use | Laboratory research only |
Mechanism of Action & Research Applications
Abaloparatide selectively binds to the parathyroid hormone receptor 1 (PTH1R), triggering signaling pathways that enhance osteoblast activity and bone formation. Its unique receptor binding profile results in rapid activation and internalization, promoting bone anabolism without significant resorption. This mechanism is critical in studying treatments for osteoporosis, fracture healing, and bone regenerative medicine.
Research applications include:
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Osteoporosis disease models
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Bone metabolism studies
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Skeletal regeneration research
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Evaluation of bone anabolic agents
Side Effects (For Research Context Only)
In laboratory models, abaloparatide may influence:
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Bone remodeling markers
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Cellular proliferation of osteoblasts
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Calcium metabolism in experimental systems
Disclaimer
is intended solely for laboratory research use and is not approved for diagnostic, therapeutic, or clinical use.
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