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Difelikefalin is a synthetic peptide and a selective kappa opioid receptor (KOR) agonist known for its peripheral activity. It shows promise in research related to pain modulation and pruritus (itch) relief. Manufactured at 99.98% purity under GMP conditions, Difelikefalin is intended solely for laboratory research.?For wholesale prices, other specifications and uses, please consult our staff?
Difelikefalin (also known as CR845) is a peripherally restricted and selective kappa opioid receptor agonist peptide. Unlike traditional opioids, Difelikefalin does not significantly cross the blood-brain barrier, minimizing central nervous system side effects. It acts primarily on peripheral KORs, modulating pain signals and itch responses in experimental models. This unique mechanism makes Difelikefalin a valuable tool in preclinical research for pain management, especially in conditions like chronic pain, neuropathic pain, and pruritus.
| Parameter | Details |
|---|---|
| Product Name | Difelikefalin |
| Synonyms | CR845 |
| CAS Number | 1024828-77-0 |
| Purity | 99.98% (HPLC) |
| Molecular Formula | C44H66N12O12 |
| Molecular Weight | Approx. 946.06 Da |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in water and aqueous buffers |
| Storage | Store at –20°C, protect from light and moisture |
| GMP Compliance | Yes |
| Intended Use | Laboratory research only |
Difelikefalin selectively activates kappa opioid receptors located on peripheral sensory neurons and immune cells. Its peripheral restriction avoids typical opioid-related central nervous system effects such as sedation or addiction potential. This selective action modulates peripheral pain signals and inhibits itch pathways, making it a potent agent in the study of chronic pain, neuropathic pain, and pruritus mechanisms.
Research uses include:
Investigating peripheral analgesic pathways
Studying mechanisms of chronic and neuropathic pain
Exploring therapeutic targets for pruritus
Evaluating opioid receptor pharmacology with minimized CNS effects
In experimental settings, Difelikefalin may cause transient changes in nociceptive signaling or immune cell activity. No central nervous system-related adverse effects are expected due to its peripheral action.
is intended solely for laboratory research use and is not approved for clinical or therapeutic applications.
| 重量 | 1 公斤 |
|---|---|
| 尺寸 | 26 × 23 × 26 厘米 |
Difelikefalin is a selective kappa opioid receptor agonist peptide used in research on pain and itch mechanisms.
The CAS number is 1024828-77-0.
It activates peripheral kappa opioid receptors to modulate pain and reduce itch without significant central nervous system effects.
It is used in studies of chronic pain, neuropathic pain, pruritus, and opioid receptor pharmacology.
Yes, it is manufactured in a GMP-compliant facility.
The purity is 99.98%.
Store at –20°C, protected from light and moisture.
No, it is intended for laboratory research only.
It selectively targets peripheral kappa opioid receptors, minimizing central side effects.
Because of its unique peripheral action, it helps study non-addictive analgesic mechanisms.
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