Description

BIO-11006 Acetate is a refined peptide analog derived from the first ten amino acids of the MANS peptide, designed to competitively inhibit the MARCKS (myristoylated alanine-rich C kinase substrate) protein. MARCKS plays key roles in regulating actin dynamics, mucin secretion, and inflammatory responses via calcium-calmodulin and PKC pathways. By disrupting MARCKS’ membrane association, BIO-11006 attenuates processes like cytokine secretion and neutrophil trafficking in airway inflammation models. Studies in murine lungs show it significantly suppresses ozone or LPS-induced neutrophil infiltration and key cytokines like IL-6, TNF, and KC, more effectively than MANS itself. With 99.92% purity and GMP-grade production, this peptide is a reliable choice for respiratory inflammation, immunology, and cell signaling research.

BIO-11006 Acetate Product Category

Peptide Signal Modulators — specialized peptides targeting intracellular signaling proteins, used in respiratory, immunology, and cell motility studies.

Product Specifications

BIO-11006 Acetate Mechanism of Action & Research Applications

MARCKS associates with cell membranes to regulate actin structure, vesicle trafficking, and signal transduction. BIO-11006 competes with MARCKS for membrane binding, displacing it and thereby disrupting cortical cytoskeletal dynamics and mucin secretion. This mechanism mitigates inflammation and mucus overproduction in pulmonary models. It’s been used to explore:

• Airway inflammation and mucin regulation

• Ozone or allergen-induced neutrophil recruitment

• Cytokine secretion pathways (IL-6, TNF, KC)

• Intracellular signaling disruption via MARCKS modulation

BIO-11006 Acetate Side Effects (For Research Context Only)

In preclinical use, BIO-11006 shows low systemic toxicity. However, inhibition of MARCKS signaling may affect cellular motility, secretion, and immune cell function—consider this when designing inflammatory or migration-related models.

Logistics Transportation

All shipments are delivered with transport insurance and expedited handling. We ensure 100% compensation for any lost, detained, or damaged package.

Disclaimer

BIO-11006 Acetate is strictly for laboratory research use only. It is not approved for clinical, therapeutic, veterinary, or diagnostic applications.