Description

TRV-120027, also known as TRV027 TFA, is a novel peptide-based analog of angiotensin II that uniquely biases signaling toward ?-arrestin pathways at the angiotensin II type 1 receptor (AT1R), while inhibiting traditional G-protein–mediated vasoconstriction. This pharmacological profile enables simultaneous promotion of vasodilation, enhancement of cardiomyocyte contractility, and anti-apoptotic actions. These effects combine to provide potent cardioprotection, particularly relevant in acute heart failure settings. Developed under GMP conditions with high pharmacological grade purity (?98%), TRV-120027 is an advanced research tool for cardiovascular, renal, and pharmacodynamic investigation.

Product Category

Cardioprotective Biased Ligand Peptides — synthetic peptides that selectively activate signaling bias, used in heart failure, cardiovascular modeling, and receptor-signaling research.

Product Specifications

Mechanism of Action & Research Applications

TRV-120027 binds AT1R and shifts its signaling from G-protein–mediated vasoconstriction to ?-arrestin–mediated cardioprotective responses. Key actions include:

• Vasodilation by antagonizing G-protein pathways

• Enhanced cardiomyocyte contractility via ?-arrestin engagement

• Anti-apoptotic effects, aiding cell survival in cardiac stress
  In heart failure models, especially when combined with diuretics like furosemide, TRV-120027 reduces cardiac preload and afterload, maintains renal performance, and enhances cardiac output—making it highly relevant for studies on acute heart failure, renal function, and biased agonist pharmacotherapeutics.

Side Effects (For Research Context Only)

Experimental studies show effective hemodynamic targeting at controlled doses. Researchers should monitor cardiovascular markers to avoid hypotension. The ?-arrestin bias limits typical angiotensin II–mediated side effects, but safety monitoring remains essential.

Logistics Transportation

All shipments are insurance-covered to guarantee safe and prompt delivery. We offer 100% compensation for any lost, detained, or damaged items.

Disclaimer

This product is strictly intended for laboratory research use only. It is not approved for therapeutic, clinical, or veterinary purposes.