Description

CGRP (mouse), or calcitonin gene-related peptide beta, is a naturally occurring neuropeptide expressed in mouse sensory neurons. As a potent vasodilator, it regulates systemic and local blood flow, contributes to neurogenic inflammation, and plays roles in pain signaling. Preclinical studies show peripheral administration of CGRP induces migraine-like behaviors in mice—such as light aversion and spontaneous pain—as well as metabolic and gastrointestinal changes. Its multi-system effects make it invaluable for exploring neurovascular, inflammatory, metabolic, and pain-oriented research. Manufactured to GMP standards with purity 99.77%, CGRP (mouse) serves as a high-quality tool for mechanistic and preclinical investigations.

Product Specifications

Mechanism of Action & Research Applications

CGRP (mouse) targets CGRP receptors (CLR + RAMP1) on vascular and sensory nerve cells, triggering vasodilation and modulating inflammatory responses and pain pathways. In mice, CGRP administration induces migraine-like symptoms (e.g., light aversion, facial grimace, and diarrhea), demonstrating its role in sensory and pain modulation. It’s also involved in appetite and metabolism regulation, reducing food intake and altering metabolic hormone levels following treatment. These properties make it a primary research agent in models of migraine, vascular physiology, pain, and metabolic dysfunction.

Side Effects (For Research Context Only)

In experimental models, administration of ?-CGRP may lead to:

• Vasodilation resulting in hypotension

• Pain behaviors including grimacing and light sensitivity

• Gastrointestinal responses like diarrhea

• Altered feeding behavior or metabolism

Researchers should monitor vital signs, behavior, and metabolic end points when using this peptide.

Logistics Transportation

All orders are shipped with full transport insurance and expedited handling. We guarantee 100% compensation for any lost, detained, or damaged packages to ensure smooth and secure delivery.

Disclaimer

CGRP (mouse) is intended strictly for laboratory research use only. It is not approved for clinical, diagnostic, therapeutic, or veterinary applications.