Description

Plecanatide is an orally active, 16-amino-acid cyclic peptide analogue of the human gastrointestinal hormone uroguanylin. It selectively activates guanylate cyclase-C (GC-C) receptors on intestinal epithelial cells, raising intracellular cGMP levels, stimulating chloride and bicarbonate secretion via CFTR channels, and increasing intestinal fluid, thereby accelerating bowel transit. It also exhibits anti-inflammatory effects in experimental colitis models. Manufactured in a GMP-compliant facility with ?99.93% purity, Plecanatide ensures reliable performance for research applications. For laboratory research use only.

Product Specifications

Mechanism of Action & Research Applications

Plecanatide activates GC-C receptors in the intestinal mucosa, elevating intracellular cGMP. This stimulates CFTR-mediated chloride and bicarbonate secretion into the gut lumen, increasing hydration and accelerating motility. It also reduces colonic inflammation in animal models of colitis. Useful in research exploring gastrointestinal secretion, motility, and inflammatory pathways. For laboratory research use only.

Side Effects (For Reference Only in Models)

In preclinical settings, elevated GC-C activation may lead to excessive intestinal fluid secretion and rapid transit. Experimental models may also exhibit local epithelial responses or mild irritation. These findings are solely for experimental context—for laboratory research use only.

Disclaimer

Plecanatide is intended strictly for laboratory research use only. It is not approved for human or veterinary use. Handling should follow institutional safety and disposal protocols.