Description

Histrelin Acetate (CAS 220810-26-4) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) with enhanced potency. Synthesized under GMP conditions, it boasts a purity of ?99.90%, ensuring high-quality standards for laboratory applications.

Upon administration, Histrelin Acetate binds to and activates GnRH receptors, leading to an initial increase in serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels. Prolonged administration results in pituitary GnRH receptor desensitization and inhibition of LH and FSH secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression. In females, prolonged administration results in decreased estradiol production.

This compound is intended strictly for laboratory research use and is not approved for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Histrelin Acetate functions by binding to and activating GnRH receptors, leading to increased secretion of LH and FSH. This results in elevated serum testosterone levels in males and estradiol levels in females. Prolonged administration leads to desensitization of GnRH receptors and inhibition of gonadal hormone production.

In laboratory research, Histrelin Acetate is utilized to study hormonal regulation, reproductive endocrinology, and the effects of GnRH receptor modulation. It is also used in the development of treatments for hormone-sensitive conditions such as prostate cancer and endometriosis.

Disclaimer

This product is intended strictly for laboratory research use only. It is not approved for human or veterinary use. Handle according to institutional safety protocols.