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Reversin 121 – High Purity 99.08% – GMP Manufacturer
$2.00
Reversin 121 is a GMP-grade, high-purity peptide that reverses P-glycoprotein-mediated multidrug resistance. Ideal for cancer biology and transporter studies. For laboratory research use only.?For wholesale prices, other specifications and uses, please consult our staff?
Description
Reversin 121 (CAS No. 174630-04-7) is a hydrophobic peptide chemosensitizer known for its ability to reverse P-glycoprotein (MDR1)-mediated multidrug resistance. It binds with high affinity to the P-glycoprotein transporter (Kd ~77 nM) and modulates its ATPase activity in membrane and cellular systems. This makes it especially relevant for research in cancer drug resistance, transporter function, and pharmacological sensitization models. Manufactured under GMP conditions and high purity (~99%), Reversin 121 delivers consistent and reproducible performance for experimental use. Intended strictly for laboratory research use only.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Reversin 121 |
| Synonyms | BOC-ASP(OBZL)-LYS(Z)-OTBU; dipeptide derivative |
| CAS No. | 174630-04-7 |
| Purity | ? 99% (GMP-grade, HPLC) |
| Molecular Formula | C??H??N?O? |
| Molecular Weight | Approx. 641.8 g/mol |
| Mechanism | Hydrophobic peptide chemosensitizer and P-glycoprotein activity modulator |
| Binding Affinity | Kd ? 77 nM for P-glycoprotein |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in DMSO, DMF; moderate solubility in ethanol or buffer mixtures |
| Storage Conditions | Store at –20 °C; protect from light and moisture |
| Manufacturing Standard | GMP-compliant |
| Applications | Cancer cell drug resistance research, P-glycoprotein modulation, transporter assays |
| Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
Mechanism of Action:
Reversin 121 functions as a hydrophobic peptide chemosensitizer by binding to P-glycoprotein (MDR1) and modulating its ATPase activity. With a binding affinity in the nanomolar range, it can effectively reverse drug resistance by interfering with transporter-mediated efflux.
Research Applications:
Cancer Drug Resistance Models: Used to sensitize resistant tumor cells by inhibiting P-glycoprotein function.
Transporter Biology Studies: Valuable for exploring mechanisms of P-glycoprotein activity and ATPase regulation.
Drug Interaction Assays: Suitable for assays highlighting transporter-mediated drug distribution and accumulation.
Pharmacology & Oncology Research: Supports investigation of strategies to overcome multidrug resistance.
Side Effects (Research Context Only)
Reversin 121 is intended for in vitro and preclinical research use only. No human or clinical safety data is available. Standard laboratory safety protocols should be followed.
Disclaimer
Reversin 121 is strictly for laboratory research use only. It is not approved for clinical, therapeutic, or diagnostic applications. Handle according to institutional safety guidelines.
Additional information
| Weight | 0.7 kg |
|---|---|
| Dimensions | 63 × 42 × 63 cm |
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