Bamadutide – High Purity 99.96% – GMP Manufacturer

描述

Bamadutide (CAS No.?1596343-09-7), also known as SAR425899, is a synthetic peptide that acts as a dual agonist for the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). It induces cAMP accumulation in HEK293 cells expressing human GLP-1R or GCGR with EC50s of 1 and 3.5 pM, respectively. Bamadutide has been shown to improve postprandial glucose control by enhancing ?-cell function and slowing glucose absorption in vivo.

This compound has potential applications in the research of type 2 diabetes, obesity, and other metabolic disorders. It has been studied for its ability to reduce food intake, decrease blood glucose levels, and promote weight loss in animal models. Bamadutide is manufactured under GMP standards with a purity of 99.96%, ensuring consistency and reliability for experimental use.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action:
Bamadutide is a synthetic analog that selectively activates both the GLP-1R and GCGR. Its high affinity for these receptors leads to increased cAMP production, enhancing insulin secretion and ?-cell function while slowing gastric emptying. This dual agonism improves postprandial glucose control and has potential benefits in metabolic disorders.

Research Applications:

• Type 2 Diabetes Research: Investigating treatments that enhance insulin secretion and ?-cell function.

• Obesity Studies: Exploring compounds that reduce food intake and promote weight loss.

• Metabolic Disorder Research: Studying the effects of dual receptor agonists on glucose metabolism and insulin sensitivity.

  

Side Effects (Research Context Only)

Bamadutide is intended for laboratory research use only. In preclinical studies, it has been shown to reduce food intake and body weight without significant adverse effects. However, as with all experimental compounds, appropriate safety protocols should be followed during handling and administration.

Disclaimer

Bamadutide is strictly for laboratory research use only. It is not approved for clinical, diagnostic, or therapeutic purposes. Users should adhere to institutional safety guidelines and regulatory requirements when handling this compound.