Description

Ziconotide TFA (SNX-111 TFA) is the trifluoroacetate salt form of the synthetic peptide ziconotide, known for its potent and highly selective antagonism of N-type voltage-gated calcium channels (Cav2.2). By binding to these channels located at presynaptic nerve terminals, Ziconotide TFA effectively inhibits calcium influx, thereby reducing neurotransmitter release and synaptic transmission.

This mechanism makes Ziconotide TFA an invaluable peptide in research focused on chronic pain models, synaptic signaling pathways, ion channel pharmacology, and neuroprotection studies. Because N-type calcium channels are critically involved in nociceptive transmission, Ziconotide TFA provides a reliable model for understanding how modulating these channels can attenuate pain responses.

Ziconotide TFA is produced under GMP-compliant manufacturing conditions, ensuring consistent peptide purity and reliability for advanced experimental applications. With its strong selectivity and peptide-based design, it serves as a model compound for investigating the therapeutic potential of calcium channel blockers in pain management and neurological disorders.

For laboratory research use only. Not for human consumption.

Product Specifications

Mechanism of Action & Research Applications

Ziconotide TFA is a highly selective blocker of N-type voltage-gated calcium channels (VGCCs, Cav2.2). These channels are predominantly located on presynaptic neurons in the dorsal horn of the spinal cord, where they play a vital role in mediating neurotransmitter release, including glutamate, substance P, and calcitonin gene-related peptide (CGRP).

By binding directly to Cav2.2 channels, Ziconotide TFA prevents calcium influx upon depolarization. This leads to a reduction in neurotransmitter release, effectively disrupting nociceptive signaling pathways. In experimental chronic pain models, this translates into significant suppression of pain transmission at the spinal level.

Research applications include:

• Chronic pain research: Used to evaluate mechanisms of pain signaling and validate novel analgesic approaches.

• Synaptic physiology studies: Serves as a model tool for dissecting calcium-dependent neurotransmitter release.

• Ion channel pharmacology: Helps in characterizing N-type calcium channel selectivity and drug discovery.

• Neurodegenerative disease research: Explored for its ability to regulate excitotoxicity, relevant to conditions like ALS and neuropathic pain.

• Translational pain therapy studies: Provides a model compound for peptide-based pain management strategies.

Because of its high specificity, Ziconotide TFA does not affect L-type or T-type calcium channels, making it a gold-standard tool for neuroscience experiments.

Side Effects (For Reference in Research Models)

In experimental and clinical research contexts, Ziconotide and its TFA form have been associated with certain side effects due to their potent neuromodulatory activity. While these effects are primarily observed in animal or clinical models and are provided for reference only, they include:

• Dizziness or balance impairment

• Changes in mood or cognitive function

• Nausea or gastrointestinal effects

• Abnormal gait in high-dose studies

• Reversible memory impairment in some cases

• Headache and changes in blood pressure

Note: These potential side effects are documented from model and clinical data. Ziconotide TFA provided here is strictly for laboratory research use only and is not intended for therapeutic or diagnostic purposes.

Disclaimer

Ziconotide TFA is supplied strictly for laboratory research use only. It is not intended for human use, clinical applications, or diagnostic procedures. All handling should be performed by trained professionals under appropriate laboratory conditions.

 Keywords

• Ziconotide TFA

• SNX-111 TFA peptide

• N-type calcium channel blocker research

• Ziconotide TFA chronic pain research

• GMP grade Ziconotide TFA supplier

• Calcium channel antagonist peptide

• Neuroscience peptide research

• Synaptic transmission peptide

• Ziconotide TFA wholesale supplier

• Laboratory use Ziconotide TFA