Description

Product Description

Zaloganan (CAS 2759007-66-2) is a novel antimicrobial peptide (AMP) with broad-spectrum antibacterial activity, achieved primarily through disruption of bacterial membranes. As antimicrobial resistance continues to grow into a global health crisis, peptides like Zaloganan are gaining increasing attention for their potential role in next-generation anti-infective therapeutics.

Antimicrobial Peptide Background

Antimicrobial peptides are short, naturally occurring or synthetic amino acid sequences that form part of the innate immune defense in many organisms. Unlike traditional antibiotics that target specific metabolic pathways, AMPs like Zaloganan act by directly interacting with bacterial membranes, leading to rapid bacterial cell lysis and death. This mechanism makes them less prone to resistance development compared to conventional antibiotics.

Spectrum of Activity

Zaloganan has been shown to exhibit activity against a broad range of Gram-positive and Gram-negative bacteria, including multi-drug resistant (MDR) strains. Its bactericidal properties make it a versatile tool in research models studying resistant infections such as:

• Methicillin-resistant Staphylococcus aureus (MRSA)

• Vancomycin-resistant Enterococcus (VRE)

• Carbapenem-resistant Enterobacteriaceae (CRE)

• Pseudomonas aeruginosa and Acinetobacter baumannii

Research Applications

• Mechanistic Studies: Understanding how membrane-targeting peptides disrupt bacterial integrity.

• Resistance Research: Exploring AMPs as alternatives to failing antibiotics.

• Synergistic Studies: Combining AMPs like Zaloganan with existing antibiotics to enhance efficacy.

• Drug Discovery: Preclinical evaluation of peptide scaffolds for therapeutic design.

Advantages Over Traditional Antibiotics

• Rapid and direct killing of bacteria.

• Low risk of resistance due to non-specific membrane targeting.

• Broad-spectrum activity.

• Potential utility against biofilms, which are notoriously resistant to antibiotics.

Zaloganan represents a promising research compound in the fight against antimicrobial resistance, supporting studies into both fundamental microbiology and novel therapeutic approaches.

Product Specifications

Notes on Specifications

• HPLC and MS verified for quality assurance.

• Delivered sterile for research reproducibility.

• Intended for microbiology, pharmaceutical, and biomedical studies.

Mechanism of Action

Zaloganan works by disrupting bacterial membranes, a hallmark feature of antimicrobial peptides.

• Electrostatic Interaction
  Zaloganan binds preferentially to negatively charged bacterial membranes due to its cationic nature.

• Membrane Insertion
  After binding, the peptide inserts into the lipid bilayer, destabilizing the bacterial cell envelope.

• Pore Formation and Lysis
  This leads to pore formation, leakage of cellular contents, and eventual cell death.

• Broad-Spectrum Killing
  Because this mechanism is non-specific to bacterial metabolic pathways, Zaloganan is effective across diverse bacterial strains, including drug-resistant isolates.

This mode of action highlights Zaloganan as a membrane-active research peptide, distinguishing it from conventional antibiotics and offering a model for next-generation antimicrobial development.

Side Effects

Research Observations

• Zaloganan is generally effective at low micromolar concentrations.

• Minimal resistance development reported in repeated exposure studies.

Potential Limitations

• At high concentrations, some AMPs may exhibit cytotoxicity toward mammalian cells.

• Hemolytic activity is a theoretical risk and must be assessed in experimental models.

Precautions

• Use only in controlled laboratory settings.

• Not approved for therapeutic or diagnostic purposes.

Disclaimer

All information is provided strictly for research and laboratory use only. Zaloganan is not intended for human use, medical treatment, or diagnostic applications.

Keywords

Zaloganan peptide, CAS 2759007-66-2, antibacterial peptide, antimicrobial peptide, broad-spectrum antibacterial research, AMP antibacterial, peptide drug discovery, bacterial membrane disruption.

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